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Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

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  • معلومة اضافية
    • Contributors:
      Aguareles,J; Paraíso-Luna,J; Bajo-Grañeras,R; Ruiz-Calvo,A; García-Rincón,D; García-Taboada,E; Guzmán,M; Galve-Roperh,I Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. Aguareles,J; Galve-Roperh,I Departamento de Bioquímica y Biología Molecular and Instituto Universitario de Investigación Neuroquímica, Universidad Complutense, Madrid, Spain. Aguareles,J; Galve-Roperh,I Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Palomares,B; Muñoz,E Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. Palomares,B; Muñoz,E Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Córdoba, Spain. Palomares,B; Muñoz,E Hospital Universitario Reina Sofía, Córdoba, Spain. Navarrete,C Emerald Health Pharmaceuticals, San Diego, USA.; This work was supported by the MINECO grant RTC-2015-3364 to EM and IGR cofounded by the European Development Regional Fund in the Framework of the Operative Program “Reinforcement of research, technological development and innovation”. IGR was also supported by grant PI15–00310 and PI18–00941 cofinanced by the European Development Regional Fund “A way to achieve Europe” and EM by the MINECO grant SAF2017–87701-R. JA and JPL were supported by FPI and FPU program fellowship (Ministerio de Educación, Cultura y Deporte) and DGR by Fundación Tatiana de Guzmán el Bueno. BP is a predoctoral fellow supported by the i-PFIS program, Instituto de Salud Carlos III (IFI15/00022; European Social Fund “Investing in your future”).
    • بيانات النشر:
      BioMed Central Ltd.
    • الموضوع:
      2019
    • Collection:
      Sistema Sanitario Público de Andalucía (SSPA): Repositorio
    • نبذة مختصرة :
      The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated by CB1 receptors, which can elicit psychotropic effects, but other targets devoid of psychotropic activity, including CB2 and nuclear PPARγ receptors, can also be the target of specific cannabinoids. ; Yes
    • File Description:
      application/pdf
    • ISSN:
      2047-9158
    • Relation:
      https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-019-0148-x; Aguareles J, Paraíso-Luna J, Palomares B, Bajo-Grañeras R, Navarrete C, Ruiz-Calvo A, et al. Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration. Transl Neurodegener. 2019 Mar 8;8:9.; http://hdl.handle.net/10668/3148; PMC6407204
    • الرقم المعرف:
      10.1186/s40035-019-0148-x
    • الدخول الالكتروني :
      http://hdl.handle.net/10668/3148
      https://doi.org/10.1186/s40035-019-0148-x
    • Rights:
      open access
    • الرقم المعرف:
      edsbas.ADBF3828