Investigating the role of neuronal nicotinic acetylcholine receptor subtypes in the acquisition and maintenance of alcohol use disorders

Owing to the substantial comorbidity of nicotine and alcohol, this project was designed to explore the role that neuronal nicotinic acetylcholine receptors play in the development of alcohol use disorders. This study utilised well-established animal models, documenting the impact of 'binge-like' ethanol consumption on the expression of these receptors in key brain areas governing stress and reward. Only by continuing to uncover the neurological changes attributed to alcohol consumption, can we further elucidate treatment options for those affected.