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Shared T cell receptor chains in blood memory CD4+ T cells of narcolepsy type 1 patients

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Institute of Clinical Neuroimmunology Munich, Germany; Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU); Centre de Physiopathologie Toulouse Purpan (CPTP); Université Toulouse III - Paul Sabatier (UT3); Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Vinmec Research Institute of Stem cell and Gene technology (VRISG), Hanoi, Vietnam; Département de neurologie Montpellier; Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Hôpital Gui de Chauliac CHU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Université de Montpellier (UM); Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC); Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)
    • بيانات النشر:
      HAL CCSD
      Elsevier
    • الموضوع:
      2019
    • Collection:
      Université de Montpellier: HAL
    • نبذة مختصرة :
      International audience ; Convergent evidence points to the involvement of T cells in the pathogenesis of narcolepsy type 1 (NT1). Here, we hypothesized that expanded disease-specific T cell clones could be detected in the blood of NT1 patients. We compared the TCR repertoire of circulating antigen-experienced CD4+ and CD8+ T cells from 13 recently diagnosed NT1 patients and 11 age-, sex-, and HLA-DQB1*06:02-matched healthy controls. We detected a bias in the usage of TRAV3 and TRAV8 families, with public CDR3α motifs only present in CD4+ T cells from patients with NT1. These findings may offer a unique tool to identify disease-relevant antigens.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/30948158; hal-02867986; https://hal.umontpellier.fr/hal-02867986; https://hal.umontpellier.fr/hal-02867986/document; https://hal.umontpellier.fr/hal-02867986/file/S0896841119300484.pdf; PII: S0896-8411(19)30048-4; PUBMED: 30948158
    • الرقم المعرف:
      10.1016/j.jaut.2019.03.010
    • الدخول الالكتروني :
      https://hal.umontpellier.fr/hal-02867986
      https://hal.umontpellier.fr/hal-02867986/document
      https://hal.umontpellier.fr/hal-02867986/file/S0896841119300484.pdf
      https://doi.org/10.1016/j.jaut.2019.03.010
    • Rights:
      http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.AAC55C2A