Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation. ; Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.: Caspase-8 in the macrophage differentiation.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Mort cellulaire et cancer; Université de Bourgogne (UB)-IFR100 - Structure fédérative de recherche Santé-STIC-Institut National de la Santé et de la Recherche Médicale (INSERM); Santé - STIC; Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM); Lipides - Nutrition - Cancer (U866) (LNC); Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA); CHU Dijon; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon); Institut Cochin (UMR_S567 / UMR 8104); Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Service d'hématologie; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5); Department of Pharmacology and biochemistry; Virginia Commonwealth University (VCU); This study was supported by a special grant from the Ligue Nationale Contre le Cancer to ES (équipe labélisée) and a grant from the Direction Régionale de la Recherche Clinique de l'Assistance Publique des Hôpitaux de Paris to MF. SL, SC and RF were sustained by the Ligue Nationale Contre le Cancer, CR by the Association pour la Recherche contre le Cancer and EG by the Inserm.
    • بيانات النشر:
      HAL CCSD
      American Society of Hematology
    • الموضوع:
      2007
    • Collection:
      Université de Bourgogne (UB): HAL
    • نبذة مختصرة :
      Caspases have demonstrated several nonapoptotic functions including a role in the differentiation of specific cell types. Here, we show that caspase-8 is the upstream enzyme in the proteolytic caspase cascade whose activation is required for the differentiation of peripheral-blood monocytes into macrophages. On macrophage colony-stimulating factor (M-CSF) exposure, caspase-8 associates with the adaptor protein Fas-associated death domain (FADD), the serine/threonine kinase receptor-interacting protein 1 (RIP1) and the long isoform of FLICE-inhibitory protein FLIP. Overexpression of FADD accelerates the differentiation process that does not involve any death receptor. Active caspase-8 cleaves RIP1, which prevents sustained NF-kappaB activation, and activates downstream caspases. Together these data identify a role for caspase-8 in monocytes undergoing macrophagic differentiation, that is, the enzyme activated in an atypical complex down-regulates NF-kappaB activity through RIP1 cleavage.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/17047155; inserm-00144778; https://inserm.hal.science/inserm-00144778; https://inserm.hal.science/inserm-00144778/document; https://inserm.hal.science/inserm-00144778/file/art_31_Rebe_et_al_Blood.pdf; PUBMED: 17047155; PUBMEDCENTRAL: PMC2492986
    • الرقم المعرف:
      10.1182/blood-2006-03-011585
    • الدخول الالكتروني :
      https://inserm.hal.science/inserm-00144778
      https://inserm.hal.science/inserm-00144778/document
      https://inserm.hal.science/inserm-00144778/file/art_31_Rebe_et_al_Blood.pdf
      https://doi.org/10.1182/blood-2006-03-011585
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.A88F5E27