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Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents: evidence for herd protection from the UK MenACWY programme

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  • معلومة اضافية
    • بيانات النشر:
      Elsevier
    • الموضوع:
      2022
    • Collection:
      University of Nottingham: Repository@Nottingham
    • نبذة مختصرة :
      Objective: Serogroup W and Y invasive meningococcal disease increased globally from 2000 onwards. Responding to a rapid increase in serogroup W clonal complex 11 (W:cc11) invasive meningococcal disease, the UK replaced an adolescent booster dose of meningococcal C conjugate vaccine with quadrivalent MenACWY conjugate vaccine in 2015. By 2018, the vaccine coverage in the eligible school cohorts aged 14 to 19 years was 84%. We assessed the impact of the MenACWY vaccination programme on meningococcal carriage. Methods: An observational study of culture-defined oropharyngeal meningococcal carriage prevalence before and after the start of the MenACWY vaccination programme in UK school students, aged 15 to 19 years, using two cross-sectional studies: 2014 to 2015 “UKMenCar4” and 2018 “Be on the TEAM” (ISRCTN75858406). Results: A total of 10 625 participants preimplementation and 13 434 postimplementation were included. Carriage of genogroups C, W, and Y (combined) decreased from 2.03 to 0.71% (OR 0.34 [95% CI 0.27–0.44], p < 0.001). Carriage of genogroup B meningococci did not change (1.26% vs 1.23% [95% CI 0.77–1.22], p = 0.80) and genogroup C remained rare (n = 7/10 625 vs 17/13 488, p = 0.135). The proportion of serogroup positive isolates (i.e. those expressing capsule) decreased for genogroup W by 53.8% (95% CI –5.0 to 79.8, p = 0.016) and for genogroup Y by 30.1% (95% CI 8.9–46·3, p = 0.0025). Discussion: The UK MenACWY vaccination programme reduced carriage acquisition of genogroup and serogroup Y and W meningococci and sustained low levels of genogroup C carriage. These data support the use of quadrivalent MenACWY conjugate vaccine for indirect (herd) protection.
    • Relation:
      https://nottingham-repository.worktribe.com/output/13464584; Clinical Microbiology and Infection; Volume 28; Issue 12; Pagination 1649.e1-1649.e8
    • الرقم المعرف:
      10.1016/j.cmi.2022.07.004
    • الدخول الالكتروني :
      https://doi.org/10.1016/j.cmi.2022.07.004
      https://nottingham-repository.worktribe.com/file/13464584/1/1-s2.0-S1198743X22003688-main%20Final%20Published
      https://nottingham-repository.worktribe.com/output/13464584
    • Rights:
      openAccess ; https://creativecommons.org/licenses/by/4.0/
    • الرقم المعرف:
      edsbas.A84FC451