Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

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Stanford, CA, USA. 22Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. 23Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. 24Department of Biostatistics, University of Liverpool, Liverpool, UK. 25Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK. 26Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy. 27Medical Sciences, Uppsala University Hospital, Uppsala, Sweden. 28Nuffield Department of Medicine, Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK. 29Nuffield Department of Medicine, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. 30The Broad Institute of MIT and Harvard, Cambridge, MA, USA. 31Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 32Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK. 33NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK. 34Cardiovascular Department, Azienda Ospedaliera Universitaria Integrata of Trieste, Trieste, Italy. 35Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. 36Department of Clinical Physiology, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center Tampere University, Tampere, Finland. 37Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. 38Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, Finland. 39Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. 40Department of Cardiology, Finnish Cardiovascular Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 41Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. 42Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. 43Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. 44Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 45Cardiology Division, University Hospital, Basel, Switzerland. 46Population Health Research Institute, McMaster University, Hamilton, ON, Canada. 47Institute of Clinical Chemistry, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland. 48Labormedizinisches Zentrum Dr. Risch, Vaduz, Liechtenstein. 49Private University of the Principality of Liechtenstein, Triesen, Liechtenstein. 50Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec, QC, Canada. 51Department of Pediatrics, Tampere University Hospital, Tampere, Finland. 52Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 53Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. 54Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. 55Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. 56CARIM School for Cardiovascular Diseases, Maastricht Center for Systems Biology (MaCSBio), Department of Biochemistry, and Department of Physiology, Maastricht University, Maastricht, The Netherlands. 57Department of Medical Informatics Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 58Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. 59Icelandic Heart Association, Kopavogur, Iceland. 60Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 61Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA. 62School of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. 63The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 64The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 65Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. 66Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA. 67Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA. 68DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. 69Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. 70Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. 71Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. 72IBE, Faculty of Medicine, LMU Munich, Munich, Germany. 73Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany. 74German Center for Diabetes Research, Neuherberg, Germany. 75Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 76Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 77Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK. 78NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK. 79Genomics plc, Oxford, UK. 80Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA. 81Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. 82Cardiology Department, St. Vincent's Hospital, Darlinghurst, NSW, Australia. 83St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Kensington, NSW, Australia. 84Department of Cardiovascular Medicine, University of Iowa, Iowa City, IA, USA. 85Laboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark. 86Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. 87Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. 88Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. 89Department of Cardiology, Clinical Sciences, Wallenberg Center for Molecular Medicine, Lund University Diabetes Center, Lund University and Skane University Hospital, Lund, Sweden. 90Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. 91Department of Biostatistics, University of Washington, Seattle, WA, USA. 92Department of Epidemiology, University of Washington, Seattle, WA, USA. 93Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. 94Cardiology Division, University of Washington, Seattle, WA, USA. 95Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK. 96Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. 97Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. 98Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. 99Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. 100DZHK (German Centre for Cardiovascular Research), Greifswald, Germany. 101Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany. 102Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine and University of Greifswald, Greifswald, Germany. 103Finnish Institute for Health and Welfare, Helsinki, Finland. 104Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland. 105Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. 106Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA. 107Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. 108Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. 109Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands. 110Department of Biomedical Sciences, University of Sassari, Sassari, Italy. 111Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA. 112Laboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD, USA. 113Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, USA. 114National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA. 115Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. 116Center for Human Genetic Research and Cardiovascular Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA. 117Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 118The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK. 119Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK. 120Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. 121Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. 122Department of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 123Human Genotyping Facility Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. 124Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA. 125Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, OH, USA. 126Departments of Epidemiology and Medicine, Gillings School of Global Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC, USA. 127Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. 128McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 129Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA. 130Cardiology, Geneva University Hospitals, Geneva, Switzerland. 131Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA. 132Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. 133Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA. 134Division of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, NC, USA. 135Barts Heart Centre, St Bartholomews Hospital, London, UK. 136Institute of Cardiovascular Science, University College London, London, UK. 137Department of Mechanical Engineering, University College London, London, UK. 138Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland. 139School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. 140Section of Cardiovascular Medicine and Section of Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. 141Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. 142Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA. 143Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's, University of London, London, UK. 144Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. slubitz@mgh.harvard.edu. 145Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. slubitz@mgh.harvard.edu. 146Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA. slubitz@mgh.harvard.edu. 147William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk. 148National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.

Nature Publishing Group

2020

Hirsla - Landspítali University Hospital research archive

2041-1723

https://www.nature.com/articles/s41467-020-15706-x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242331/; Ntalla I, Weng LC, Cartwright JH, et al. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nat Commun. 2020;11(1):2542. Published 2020 May 21. doi:10.1038/s41467-020-15706-x; http://hdl.handle.net/2336/621471; Nature communications

10.1038/s41467-020-15706-x

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