Étude du contrôle sémantique auprès des patients opérés d’un gliome diffus de bas grade en condition éveillée

Semantic control remains a poorly studied field. Nevertheless, it plays an important role in our relationship to the world by the use of language and by the understanding of the contextdependent environment. Cognitive neurosciences studies allow us to better understand this process and to identify the different cortico-subcortical brain structures implicated in the semantic system chiefly by carrying out research on patients with brain lesions which then permits the most suitable health care. Our study aims at studying the semantic control in diffuse low-grade patients who have underwent a surgery by Professor Hugues Duffau at Gui de Chauliac, University Hospital of Montpellier. In order to achieve this, we have recruited a population of individuals divided into two groups with healthy control patient and diffuse low-grade patients to whom we have carried out a semantic protocol thanks to computer-programmed tests by means of R software. These tests are designed to assess on one hand the efficacy of semantic control with semantic and non-semantic tasks in verbal and non-verbal modalities and on the other hand enable to explore the involved cerebral structures. Our results highlight the presence of a semantic control deficit in diffuse lowgrade patients compared to healthy control with an overall cognitive slowdown. Yet, we observe no hemispheric lateralization of semantic control. Altogether, it would indicates it as bilateral with a preference of the verbal modality in the left hemisphere. These results highlight the importance of taking into account the assessment of semantic control in the speech therapy of patients with brain lesions. ; Le contrôle sémantique est un domaine encore peu étudié à ce jour. Pourtant celui-ci joue un rôle primordial dans notre rapport au monde à travers l’utilisation du langage et la compréhension de l’environnement selon le contexte. Les études en neurosciences cognitives permettent de mieux comprendre le fonctionnement de ce système et d’identifier les différentes structures ...