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Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis

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  • معلومة اضافية
    • بيانات النشر:
      Wiley
    • Collection:
      CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas)
    • نبذة مختصرة :
      BACKGROUND: Chagas disease is caused by the parasite Trypanosoma cruzi and is endemic in much of Latin America. With increased globalisation and immigration, it is a risk in any country, partly through congenital transmission. The frequency of congenital transmission is unclear. OBJECTIVE: To assess the frequency of congenital transmission of T. cruzi. SEARCH STRATEGY: PubMed, Journals@Ovid Full Text, EMBASE, CINAHL, Fuente Academica and BIREME databases were searched using seven search terms related to Chagas disease or T. cruzi and congenital transmission. SELECTION CRITERIA: The inclusion criteria were the following: Dutch, English, French, Portuguese or Spanish language; case report, case series or observational study; original data on congenital T. cruzi infection in humans; congenital infection rate reported or it could be derived. This systematic review included 13 case reports/series and 51 observational studies. DATA COLLECTION AND ANALYSIS: Two investigators independently collected data on study characteristics, diagnosis and congenital infection rate. The principal summary measure - the congenital transmission rate - is defined as the number of congenitally infected infants divided by the number of infants born to infected mothers. A random effects model was used. MAIN RESULTS: The pooled congenital transmission rate was 4.7% (95% confidence interval: 3.9-5.6%). Countries where T. cruzi is endemic had a higher rate of congenital transmission compared with countries where it is not endemic (5.0% versus 2.7%). CONCLUSIONS: Congenital transmission of Chagas disease is a global problem. Overall risk of congenital infection in infants born to infected mothers is about 5%. The congenital mode of transmission requires targeted screening to prevent future cases of Chagas disease. ; Fil: Howard, Elizabeth J. University of Tulane; Estados Unidos ; Fil: Xiong, Xu. University of Tulane; Estados Unidos ; Fil: Carlier, Yves. Université Libre de Bruxelles; Bélgica ; Fil: Sosa-estani, Sergio Alejandro. Dirección ...
    • File Description:
      application/pdf
    • ISSN:
      1470-0328
      1471-0528
    • Relation:
      info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914719/; http://hdl.handle.net/11336/32613; Buekens, Pierre; Sosa-estani, Sergio Alejandro; Carlier, Yves; Xiong, Xu; Howard, Elizabeth J.; Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis; Wiley; BJOG - An International Journal of Obstetrics and Gynaecology; 121; 1; 8-2013; 22-33; CONICET Digital; CONICET
    • الدخول الالكتروني :
      http://hdl.handle.net/11336/32613
    • Rights:
      info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
    • الرقم المعرف:
      edsbas.A2DA5C3E