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Genotoxic effect of alkaloids

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  • معلومة اضافية
    • الموضوع:
      1991
    • Collection:
      Universidade Federal do Rio Grande do Sul (UFRGS): Lume
    • نبذة مختصرة :
      Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotoxícity in the presence of a metabolic activation mixture. Voacristine isolated from the leaves of Ervatamia coronaria shows in vivo cytostatic and mu tagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.
    • File Description:
      application/pdf
    • ISSN:
      0074-0276
    • Relation:
      Memorias do Instituto Oswaldo Cruz : an International Journal of Biological and Biomedical Research. Rio de Janeiro. Vol. 86, supl. II (1991), p. 71-74; http://hdl.handle.net/10183/19219; 000003844
    • الدخول الالكتروني :
      http://hdl.handle.net/10183/19219
    • Rights:
      Open Access
    • الرقم المعرف:
      edsbas.A252854C