Systematic review: impact of constipation on quality of life in adults and children

International audience ; Background Comparison of quality of life (QOL) across disease areas requires the use of appropriate tools. Although many studies have investigated QOL in constipation, most used disease-specific tools that are inappropriate for cross-comparisons. Aims This review aimed to identify studies of QOL in constipation and to compare these results with other chronic conditions Methods A comprehensive literature search identified studies in constipation that used a generic QOL tool. Results were statistically pooled where possible, and compared to published results using the same tools in other chronic conditions. Results 13 qualifying studies were identified, 10 in adults and 3 in children. Results from 8 studies using the SF-36/12 tools were pooled; the remaining 5 were narratively reported. Mental and physical components of QOL scores were consistently impaired in both adult and child populations, with greatest impact being seen in secondary care studies. Mental health effects predominated over physical domains. The magnitude of impact was comparable to that seen in patients with allergies, musculoskeletal conditions and inflammatory bowel disease. Conclusion The impact of constipation on QOL is significant and comparable to other common chronic conditions. Improving management may prove offer an effective way of improving QOL for a substantial number of patients.