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Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia

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  • معلومة اضافية
    • Contributors:
      Institut des Sciences de l'Evolution de Montpellier (UMR ISEM); Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement IRD : UR226-Centre National de la Recherche Scientifique (CNRS); Processus Infectieux en Milieu Insulaire Tropical (PIMIT); Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS); Institut Pasteur de Tunis; Pasteur Network (Réseau International des Instituts Pasteur); Centre de Biochimie Structurale Montpellier (CBS); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS); Sequencing data were produced through the technical facilities of the LabEX "Centre Méditerranéen de l'Environnement et de la Biodiversité" in the GENSEQ plateform. This work was funded by the French ANR (project “CIAWOL” ANR-16-CE02-0006-01 and ANR-10-BINF-0003).; ANR-16-CE02-0006,CIAWOL,Bases moléculaire et cellulaire de la diversité phénotypique de l'incompatibilté cytoplasmique chez les insectes(2016); ANR-10-BINF-0003,Bip:Bip,Paradigme d'inference bayesienne pour la Biologie structurale in silico(2010)
    • بيانات النشر:
      CCSD
      Nature Publishing Group
    • الموضوع:
      2018
    • Collection:
      Réseau International des Instituts Pasteur, Paris: HAL-RIIP
    • نبذة مختصرة :
      International audience ; Culex pipiens mosquitoes are infected with Wolbachia (wPip) that cause an important diversity of cytoplasmic incompatibilities (CIs). Functional transgenic studies have implicated the cidA-cidB operon from wPip and its homolog in wMel in CI between infected Drosophila males and uninfected females. However, the genetic basis of the CI diversity induced by different Wolbachia strains was unknown. We show here that the remarkable diversity of CI in the C. pipiens complex is due to the presence, in all tested wPip genomes, of several copies of the cidA-cidB operon, which undergoes diversification through recombination events. In 183 isofemale lines of C. pipiens collected worldwide, specific variations of the cidA-cidB gene repertoires are found to match crossing types. The diversification of cidA-cidB is consistent with the hypothesis of a toxin–antitoxin system in which the gene cidB co-diversifies with the gene cidA, particularly in putative domains of reciprocal interactions.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/29358578; PUBMED: 29358578; PUBMEDCENTRAL: PMC5778026
    • الرقم المعرف:
      10.1038/s41467-017-02749-w
    • الدخول الالكتروني :
      https://riip.hal.science/pasteur-01728878
      https://riip.hal.science/pasteur-01728878v1/document
      https://riip.hal.science/pasteur-01728878v1/file/Culex%20pipiens.pdf
      https://doi.org/10.1038/s41467-017-02749-w
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.A1E9F0A6