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Hypothetical model of VitD3 effects in D 3 -MDMs during DENV-2 infection.

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  • معلومة اضافية
    • الموضوع:
      2021
    • Collection:
      Smithsonian Institution: Digital Repository
    • نبذة مختصرة :
      (A) VitD3 can be found as inactive form 25(OH) 2 D2 (calcidiol), as active form 1,25(OH) 2 D3 (calcitriol), or be converted from inactive to active form within the cell by the action of CYP7B1. VitD3 interacts with the vitamin D receptor (VDR) present in the nuclei and associates then, with the nuclear receptor retinoid X receptor (RXR). Together, they act as transcription factors that will increase the expression of genes that have vitamin D response elements (VDRE) [ 58 , 59 ]. Genomic effects of VitD3 during DENV-2 infection include decreased expression of IL-6, TNF-α, RIG-I, TLR3, TLR7 and decreased production of reactive oxygen species (ROS). Since ROS can induce mitochondrial damage and then increase activation and expression of TLR9 [ 28 ], VitD3 reduced TLR9 expression indirectly. (B) As a non-genomic effect, VitD3 can bind to VDR that is initially bound to STAT1 [ 29 ], and indirectly enhance the activity of the JAK-STAT signaling pathway and IFN-I activity, thus increasing expression of PKR and OAS1.
    • Relation:
      https://figshare.com/articles/figure/Hypothetical_model_of_VitD3_effects_in_D_sub_3_sub_-MDMs_during_DENV-2_infection_/16785497
    • الرقم المعرف:
      10.1371/journal.pntd.0009873.g007
    • الدخول الالكتروني :
      https://doi.org/10.1371/journal.pntd.0009873.g007
    • Rights:
      CC BY 4.0
    • الرقم المعرف:
      edsbas.9DC4BA01