Contributors: Perception et Mémoire / Perception and Memory; Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS); Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Plasticité cellulaire et Modélisation des Maladies / Cellular Plasticity and Disease Modelling; INSERM UMR894-Centre de Psychiatrie et Neurosciences (CPN); Université Paris Descartes - Paris 5 (UPD5); The University of Texas at San Antonio (UTSA); L. K. received a fellowship from LabEx/Revive and a research grant from Inserm “Transversal program on Aging” (AGEMED). A. C. was funded by a postdoctoral fellowship from the Revive Consortium. The Lledo laboratory was supported by national funds (ANR-10-LABX-73, ANR-15-CE37-0004-01, ANR-11-IDEX-0004-02), the life insurance company “AG2R-La-Mondiale” and Laboratoire d'Excellence Revive (Investissement d'Avenir). The Kokovay laboratory acknowledges the Morrison Trust Foundation and the Barshop Institute Nathan Shock Center. The Li laboratory was funded by IP, CNRS and the Agence Nationale de la Recherche (ANR-10-LABX-73, ANR-16-CE13-0017-01), Fondation ARC (PJA 20161205028, 20181208231) and AFM-Telethon Foundation.; ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010); ANR-15-CE37-0004,SmellBrain,Dissection fonctionnelle des circuits codant pour la récompense dans le système olfactif(2015); ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011); ANR-16-CE13-0017,iCELLPLASTICITY,Plasticité cellulaire dans le vieillissement(2016)
نبذة مختصرة : International audience ; Aging is a negative regulator of general homeostasis, tissue function, and regeneration. Changes in organismal energy levels and physiology, through systemic manipulations such as calorie restriction and young blood infusion, can regenerate tissue activity and increase lifespan in aged mice. However, whether these two systemic manipulations could be linked has never been investigated. Here, we report that systemic GDF11 triggers a calorie restriction-like phenotype without affecting appetite or GDF15 levels in the blood, restores the insulin/IGF-1 signaling pathway, and stimulates adiponectin secretion from white adipose tissue by direct action on adipocytes, while repairing neurogenesis in the aged brain. These findings suggest that GDF11 has a pleiotropic effect on an organismal level and that it could be a linking mechanism of rejuvenation between heterochronic parabiosis and calorie restriction. As such, GDF11 could be considered as an important therapeutic candidate for age-related neurodegenerative and metabolic disorders.
Processing Request
No Comments.