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The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans

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  • معلومة اضافية
    • Contributors:
      Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)
    • بيانات النشر:
      HAL CCSD
      BioMed Central
    • الموضوع:
      2020
    • Collection:
      Université de Lyon: HAL
    • نبذة مختصرة :
      International audience ; Background: Meiosis is essential for sexual reproduction and generates genetically diverse haploid gametes from a diploid germ cell. Reduction of ploidy depends on active chromosome movements during early meiotic prophase I. Chromosome movements require telomere attachment to the nuclear envelope. This attachment is mediated by telomere adaptor proteins. Telomere adaptor proteins have to date been identified in fission yeast and mice. In the mouse, they form a complex composed of the meiotic proteins TERB1, TERB2, and MAJIN. No sequence similarity was observed between these three mouse proteins and the adaptor proteins of fission yeast, raising the question of the evolutionary history and significance of this specific protein complex. Result: Here, we show the TERB1, TERB2, and MAJIN proteins are found throughout the Metazoa and even in earlybranching non-bilateral phyla such as Cnidaria, Placozoa and Porifera. Metazoan TERB1, TERB2, and MAJIN showed comparable domain architecture across all clades. Furthermore, the protein domains involved in the formation of the complex as well as those involved for the interaction with the telomere shelterin protein and the LINC complexes revealed high sequence similarity. Finally, gene expression in the cnidarian Hydra vulgaris provided evidence that the TERB1-TERB2-MAJIN complex is selectively expressed in the germ line. Conclusion: Our results indicate that the TERB1-TERB2-MAJIN complex has an ancient origin in metazoans, suggesting conservation of meiotic functions.
    • Relation:
      hal-03118158; https://hal.science/hal-03118158; https://hal.science/hal-03118158/document; https://hal.science/hal-03118158/file/daCruz_BMCEvolBiol_2020.pdf
    • الرقم المعرف:
      10.1186/s12862-020-01612-9
    • الدخول الالكتروني :
      https://hal.science/hal-03118158
      https://hal.science/hal-03118158/document
      https://hal.science/hal-03118158/file/daCruz_BMCEvolBiol_2020.pdf
      https://doi.org/10.1186/s12862-020-01612-9
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.9B9AFD1C