Pengaruh Ekstrak Kulit Lidah Buaya Terhadap Kadar Gula Darah Dan Gambaran Histopatologi Pankreas Tikus Yang Diinduksi Aloksan

Diabetes mellitus is caused because the pancreas does not produce enough insulin or insulin resistance occurs. As a result, the concentration of glucose in the blood increases (hyperglycemia). Aloe vera extract (EKLB) contains active compounds (flavonoids, alkaloids, tannins, saponins, and phenolics), which have the potential to reduce blood sugar levels (KGD) and improve the histopathology of rat pancreas. This study aims to determine the effect of aloe vera skin extract on decreasing blood sugar levels and improve histopathology of rat pancreas induced by alloxan. This research is an experimental study using a randomized design complete with Randomized Design Post Test. A total of 25 rats were divided into 5 groups, namely K (-) normal groups who were fed standard food and drink. K (+) positive control group induced by alloxan 120 mg / kgBB. KP I, KP II and KP III were alloxan induced groups of 120 mg / kgBB and were treated with EKLB with doses of 87.5, 175 and 350 mg / kgBB respectively. The treatment was carried out for 28 days. Blood glucose levels were measured on day 0 as preliminary data, then on days 4-7 after induction. On the 29th day measured the KGD of the rat after EKLB treatment and made histopathological preparations for rat pancreas. The KGD data obtained were tested with one way Anova with a 95% confidence level followed by the Tukey HSD test. While the data from pancreatic histopathology observation were tested using Kruskal-Wallis and continued with Mann-Whitney. The results of the statistical test showed that the KGD and pancreatic histopathology picture of the K (+) group were significantly different from the treatment group. In the KP III group had KGD and pancreatic histopathology was not significantly different from K (-). It can be concluded that the administration of aloe vera skin extract for 28 days in hyperglycemic rats had an effect on KGD and histopathology of rat pancreas. Diabetes melitus disebabkan karena pankreas tidak memproduksi cukup insulin atau terjadi resistensi ...