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Aspects of intensive therapy of diabetic ketoacidosis in pediatric practice (literature review) ; Аспекты интенсивной терапии диабетического кетоацидоза в педиатрической практике (обзор литературы)

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      NEW TERRA Publishing House
    • الموضوع:
      2024
    • Collection:
      Messenger of ANESTHESIOLOGY AND RESUSCITATION / Вестник анестезиологии и реаниматологии
    • نبذة مختصرة :
      Diabetic ketoacidosis (DKA) is an acute and severe complication of type 1 diabetes mellitus that is associated with a high risk of cerebral edema (CE)and may result in death. DKA is characterized by acute hyperglycemia, ketonemia and metabolic acidosis in the setting of decreased levels of insulin and excessive levels of the counter regulatory hormones. Algorithms of intensive treatment of DKA include such steps as fluid replacement therapy, correction of electrolyte imbalances, and intravenous infusion of insulin, performed in order to resolve metabolic acidosis and hyperglycemia as well as to prevent the development of complications (CE and hypokalemia). The analysis of literature has shown that during fluid replacement the most preferred options are balanced crystalloid solutions (Hartman’s solution and Plasma-Lyte). Infusion therapy is divided into bolus (administration of crystalloid solutions at the rate of 10 ml / kg for 30-60 minutes) and maintenance (administration of solutions for 24-48 hours). Intravenous glucosesolutions (5–10 %) are infused when the patient’s blood glucose falls below 14–16 mmol/L. Electrolyte disturbances (hypokalemia and hyponatremia) are resolved by prompt intravenous infusion of potassium and sodium solutions. Intravenous infusion of insulin is started at the rate of 0.05–0.1 U/kg/h, not earlier than 1 hour after the initiation of fluid resuscitation. Successful treatment of DKA in pediatric practice relies on clear understanding of the pathophysiological mechanisms of this complication and knowledge of the doses of the pharmaceutical drugs and volumes of infusion solutions to be used. ; Диабетический кетоацидоз (ДКА) – острое и тяжелое осложнение сахарного диабета 1 типа, с высоким риском отека головного мозга(ОГМ) и возможным летальным исходом. ДКА характеризуется острой гипергликемией, кетонемией и метаболическим ацидозом на фонедефицита инсулина и избытка контррегуляторных гормонов. Алгоритмы интенсивной терапии при ДКА включают инфузионную терапию, коррекцию электролитных ...
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      application/pdf
    • Relation:
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    • الرقم المعرف:
      10.24884/2078-5658-2024-21-1-118-124
    • الدخول الالكتروني :
      https://www.vair-journal.com/jour/article/view/936
      https://doi.org/10.24884/2078-5658-2024-21-1-118-124
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    • الرقم المعرف:
      edsbas.999DAD8C