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Exploring pseudouridylation: dysregulation in disease and therapeutic potential.

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اقرأ أكثر
  • معلومة اضافية
    • الموضوع:
      2024
    • Collection:
      Université de Lausanne (UNIL): Serval - Serveur académique lausannois
    • نبذة مختصرة :
      Pseudouridine (Ψ), the most abundant RNA modification, plays a role in pre-mRNA splicing, RNA stability, protein translation efficiency, and cellular responses to environmental stress. Dysregulation of pseudouridylation is linked to human diseases. This review explores recent insights into the role of RNA pseudouridylation alterations in human disorders and the therapeutic potential of Ψ. We discuss the impact of the reduction of Ψ levels in ribosomal, messenger, and transfer RNA in RNA processing, protein translation, and consequently its role in neurodevelopmental diseases and cancer. Furthermore, we review the success of N1-methyl-Ψ messenger RNA vaccines against COVID-19 and the development of RNA-guided pseudouridylation enzymes for treating genetic diseases caused by premature stop codons.
    • File Description:
      application/pdf
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/38833893; info:eu-repo/semantics/altIdentifier/eissn/1879-0380; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_5728369E06963; https://serval.unil.ch/notice/serval:BIB_5728369E0696; https://serval.unil.ch/resource/serval:BIB_5728369E0696.P001/REF.pdf
    • الرقم المعرف:
      10.1016/j.gde.2024.102210
    • الدخول الالكتروني :
      https://serval.unil.ch/notice/serval:BIB_5728369E0696
      https://doi.org/10.1016/j.gde.2024.102210
      https://serval.unil.ch/resource/serval:BIB_5728369E0696.P001/REF.pdf
      http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_5728369E06963
    • Rights:
      info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0/
    • الرقم المعرف:
      edsbas.97D1C37C