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Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study

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  • معلومة اضافية
    • Contributors:
      Glasbey, J.; Ademuyiwa, A.; Adisa, A.; Alameer, E.; Arnaud, A. P.; Ayasra, F.; Azevedo, J.; Minaya-Bravo, A.; Costas-Chavarri, A.; Edwards, J.; Elhadi, M.; Fiore, M.; Fotopoulou, C.; Gallo, G.; Ghosh, D.; Griffiths, E. A.; Harrison, E.; Hutchinson, P.; Lawani, I.; Lawday, S.; Lederhuber, H.; Leventoglu, S.; Li, E.; Gomes, G. M. A.; Mann, H.; Marson, E. J.; Martin, J.; Mazingi, D.; Mclean, K.; Modolo, M.; Moore, R.; Morton, D.; Ntirenganya, F.; Pata, F.; Picciochi, M.; Pockney, P.; Ramos-De la Medina, A.; Roberts, K.; Roslani, A. C.; Kottayasamy Seenivasagam, R.; Shaw, R.; Simoes, J. F. F.; Smart, N.; Stewart, G. D.; Sullivan, R.; Sundar, S.; Tabiri, S.; Taylor, E. H.; Vidya, R.; Nepogodiev, D.; Bhangu, A.; Glasbey, J. C.; Bhangu, A. A.; Siaw-Acheampong, K.; Benson, R. A.; Bywater, E.; Chaudhry, D.; Dawson, B. E.; Evans, J. P.; Gujjuri, R. R.; Heritage, E.; Jones, C. S.; Kamarajah, S. K.; Khatri, C.; Khaw, R. A.; Keatley, J. M.; Knight, A.; Mann, H. S.; Mclean, K. A.; Mckay, S. C.; Mills, E. C.; Pellino, G.; Tiwari, A.; Simoes, J. F.; Trout, I. M.; Venn, M. L.; Wilkin, R. J.; Smart, N. J.; Moug, S.; Di Saverio, S.; Vallance, A.; Vimalchandran, D.; Evans, R. P.; Townend, P.; Mckay, S.; Isaac, J.; Satoi, S.; Coonar, A. S.; Marchbank, A.; Caruana, E. J.; Layton, G. R.; Patel, A.; Brunelli, A.; Ford, S.; Desai, A.; Gronchi, A.; Almond, M.; Tirotta, F.; Dumitra, S.; Kolias, A.
    • بيانات النشر:
      Elsevier Ltd
    • الموضوع:
      2021
    • Collection:
      Università degli Studi di Genova: CINECA IRIS
    • نبذة مختصرة :
      Background: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods: This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index <20), moderate lockdowns (20–60), and full lockdowns (>60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings: Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0·84, 95% CI 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001), remained independently ...
    • File Description:
      ELETTRONICO
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/34624250; info:eu-repo/semantics/altIdentifier/wos/WOS:000716464100026; volume:22; firstpage:1507; lastpage:1517; numberofpages:11; journal:THE LANCET ONCOLOGY; http://hdl.handle.net/11567/1066180; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85119114788
    • الرقم المعرف:
      10.1016/S1470-2045(21)00493-9
    • Rights:
      info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.975832C2