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Immunogenetics in SARS: a case-control study.

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      //www.hkmj.org/resources/supp.html
      Hong Kong
    • الموضوع:
      2010
    • Collection:
      University of Hong Kong: HKU Scholars Hub
    • نبذة مختصرة :
      Key Messages: 1. Human leukocyte antigen (HLA) genotypes from 102 SARS patients (susceptible) and 108 SARS contacts (resistant) were obtained. 2. Allelic frequencies of the Class I (HLA-A, -B, and -Cw) and Class II (HLA-DR and -DQ) genes from these genetically unrelated subjects were compared. 3. A significantly higher frequency of DRB4*01010101 was found in the SARS-susceptible than SARS-resistant group. In contrast, significantly higher frequencies of HLA-B*1502 and HLADRB3*030101 were found in the SARS-resistant than SARSsusceptible group. However, none of these associations was significant after Bonferroni correction. Further, analysis of 10/36 genetically related families did not reveal any HLA alleles associated with SARS susceptibility or resistance. 4. We could not confirm previous findings of an HLA association with susceptibility or resistance to SARS. The significance of these associations needs to be validated by further independent studies. ; published_or_final_version
    • ISSN:
      1024-2708
    • Relation:
      Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine; Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2010, v. 16 n. 5 Suppl 4, p. 29-33; 33; 183440; 5 Suppl 4; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=16&issue=5, suppl. 4&spage=29&epage=33&date=2010&atitle=Immunogenetics+in+SARS:+a+case-control+study; eid_2-s2.0-79952116458; 29; http://hdl.handle.net/10722/129473; 16
    • Rights:
      This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. ; Hong Kong Medical Journal. Copyright © Hong Kong Medical Association.
    • الرقم المعرف:
      edsbas.93376D85