Effects of tumor necrosis factor-alpha on cell cycle regulatory genes expression in C6 Glioma cells.

by Wong Kin Ling. ; Thesis (M.Phil.)--Chinese University of Hong Kong, 2002. ; Includes bibliographical references (leaves 348-373). ; Abstracts in English and Chinese. ; Abstract --- p.ii ; 撮要 --- p.iv ; Acknowledgements --- p.vi ; Table of Contents --- p.vii ; List of Abbreviations --- p.xviii ; List of Tables --- p.xxi ; List of Figures --- p.xxii ; Chapter CHAPTER 1. --- INTRODUCTION ; Chapter 1.1. --- Events happened in brain injury --- p.1 ; Chapter 1.2. --- An alternate approach based on neuronal regeneration --- p.3 ; Chapter 1.3. --- Fate of astrocytes after brain injury --- p.4 ; Chapter 1.3.1. --- General information of astrocytes --- p.4 ; Chapter 1.3.2. --- Functions of astrocytes --- p.5 ; Chapter 1.4. --- Factors relate to astrocytes proliferation --- p.7 ; Chapter 1.4.1. --- TNF-α --- p.8 ; Chapter 1.4.2. --- β adrenergic mechanism and astrocyte proliferation --- p.11 ; Chapter 1.5. --- Cell cycle-related proteins --- p.13 ; Chapter 1.5.1. --- Maturation promoting factor (MPF) --- p.15 ; Chapter 1.5.2. --- Early G1 phase --- p.16 ; Chapter 1.5.3. --- Retinoblastoma protein (pRb) --- p.18 ; Chapter 1.5.4. --- Cyclin-dependent kinase (cdk) activating kinase (Cak) --- p.19 ; Chapter 1.5.5. --- "Cyclin, cdks, cki" --- p.20 ; Chapter 1.5.5.1. --- Cyclins --- p.20 ; Chapter 1.5.5.1.1. --- Cyclin D --- p.21 ; Chapter 1.5.5.1.2. --- Cyclin E --- p.22 ; Chapter 1.5.5.1.3. --- Cyclin A --- p.23 ; Chapter 1.5.5.1.4. --- Cyclin B --- p.23 ; Chapter 1.5.5.2. --- Cyclin-dependent kinases (cdks) --- p.24 ; Chapter 1.5.5.3. --- Cyclin-dependent kinase inhibitor (cki) --- p.24 ; Chapter 1.5.5.3.1. --- INK4 proteins (inhibitors of cdk-4 and cdk-6) --- p.25 ; Chapter 1.5.5.3.2. --- p21 family proteins --- p.25 ; Chapter 1.5.5.3.2.1. --- p21 --- p.25 ; Chapter 1.5.5.3.2.2. --- p27 --- p.25 ; Chapter 1.6. --- Apoptosis related proteins --- p.26 ; Chapter 1.6.1. --- bcl-2 family --- p.26 ; Chapter 1.6.1.1. --- bcl-2 --- p.26 ; Chapter 1.6.1.2. --- bcl-x --- p.27 ; Chapter 1.6.1.3. --- bcl-xα --- p.27 ; Chapter ...