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Incidence, Carriage and Case-Carrier Ratios for Meningococcal Meningitis in the African Meningitis Belt: A Systematic Review and Meta-Analysis

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      École des Hautes Études en Santé Publique EHESP (EHESP); Département Méthodes quantitatives en santé publique (METIS); Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES); Réseau International des Instituts Pasteur (RIIP); Institut Pasteur Paris (IP); Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology; Pasteur-Cnam Risques infectieux et émergents (PACRI); Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM)-Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM); TK was financially supported by EHESP School of Public Health during a Master internship and by Université Pierre et Marie Curie (Paris 6) through a doctoral contract. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.; We are grateful to Dr. Trinquart Ludovic for advice with meta-analysis and to Dr. Boisier Pascal and Dr. Musa Hassan-King for providing additional information on their publications.
    • بيانات النشر:
      HAL CCSD
      Public Library of Science
    • الموضوع:
      2015
    • Collection:
      Institut Pasteur: HAL
    • نبذة مختصرة :
      International audience ; BackgroundTo facilitate the interpretation of meningococcal meningitis epidemiology in the “African meningitis belt”, we aimed at obtaining serogroup-specific pooled estimates of incidence, carriage and case-carrier ratios for meningococcal meningitis in the African meningitis belt and describe their variations across the endemic, hyperendemic and epidemic context.MethodsWe conducted a systematic review and meta-analysis of studies reporting serogroup-specific meningococcal meningitis monthly incidence and carriage in the same population and time period. Epidemiological contexts were defined as endemic (wet season, no epidemic), hyperendemic (dry season, no epidemic), and epidemic (dry season, epidemic).FindingsEight studies reporting a total of eighty pairs of serogroup-specific meningococcal meningitis incidence and carriage estimates were included in this review. For serogroup A, changes associated with the transition from endemic to hyperendemic incidence and from hyperendemic to epidemic incidence were 15-fold and 120-fold respectively. Changes in carriage prevalence associated with both transitions were 1-fold and 30-fold respectively. For serogroup W and X, the transition from endemic to hyperendemic incidence involved a 4-fold and 1•1-fold increase respectively. Increases in carriage prevalence for the later transition were 7-fold and 1•7-fold respectively. No data were available for the hyperendemic-epidemic transition for these serogroups. Our findings suggested that the regular seasonal variation in serogroup A meningococcal meningitis incidence between the rainy and the dry season could be mainly driven by seasonal change in the ratio of clinical cases to subclinical infections. In contrast appearance of epidemic incidences is related to a substantial increase in transmission and colonisation and to lesser extent with changes in the case-carrier ratio.ConclusionSeasonal change in the rate of progression to disease given carriage together with variations in frequency of ...
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/25658307; hal-02460566; https://ehesp.hal.science/hal-02460566; https://ehesp.hal.science/hal-02460566/document; https://ehesp.hal.science/hal-02460566/file/Incidence_Carriage_and_Case-Carrier_Ratios_for_Meningococcal_Meningitis.PDF; PUBMED: 25658307; PUBMEDCENTRAL: PMC4319942
    • الرقم المعرف:
      10.1371/journal.pone.0116725
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.92EB49B4