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Human papilloma virus‐16‐specific CD8+ T‐cell expansions characterize different clinical forms of lichen planus and not lichen sclerosus et atrophicus

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  • معلومة اضافية
    • Contributors:
      Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509 (IRMAIC); Université de Reims Champagne-Ardenne (URCA); Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity); Université Toulouse III - Paul Sabatier (UT3); Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris (IP); Service d'anatomo-pathologie Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité); Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon); Genetic skin diseases : from disease mechanism to therapies (Equipe Inserm U1163); Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Service de Dermatologie AP-HP Hôpital Saint-Louis; Hopital Saint-Louis AP-HP (AP-HP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Centre National de Référence des Papillomavirus (CNRP); Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC); Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO); IRCCS Ist Tumori Giovanni Paolo II, Bari, Italy; Partenaires INRAE; Infectiologie et Santé Publique (UMR ISP); Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); European Regional Development Fund, Grant/Award Number: MP0022856; Institut National de la Sante et de la Recherche Medicale; Region Occitanie Pyrenees-Mediterranee, Grant/Award Number: #1901175; Societe Francaise de Dermatologie et de Pathologie Sexuellement Transmissible
    • بيانات النشر:
      HAL CCSD
      Wiley
    • الموضوع:
      2023
    • Collection:
      Institut Pasteur: HAL
    • نبذة مختصرة :
      International audience ; Lichen planus (LP) is a cutaneomucosal chronic inflammatory disease characterized by a CD8 + cytotoxic T-lymphocytes (CTL) infiltrate. In erosive oral LP, we found HPV16specific activated CTL in lesions, supporting a pathogenic contribution of HPV16. Here, we investigated whether a similar scenario occurs in other clinical forms of LP and in lichen sclerosus et atrophicus (LSA), another chronic disease also affecting the mucosa and/or the skin. Blood CTL from LP and LSA patients expressed significant higher levels of granzyme B, perforin and CD107a proteins than healthy donors. Expansions of TCRVß3 + CTL, with presence of TCR clonotypes identical to those previously detected in erosive oral LP, were found both in blood and mucosal/skin lesions of LP, and not of LSA patients. These expansions were enriched with HPV16-specific CD8 + T-cells as shown by their recognition of the E7 11-20 immunodominant epitope. In LSA patients, the peripheral repertoire of CTL was oligoclonal for TCRVß6 + CTL. Finally, although patients with LP and LSA have developed antibodies against HPV16
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/36922453; hal-04075439; https://hal.inrae.fr/hal-04075439; https://hal.inrae.fr/hal-04075439/document; https://hal.inrae.fr/hal-04075439/file/2023_Viguier_Exp-Dermatol_early.pdf; PUBMED: 36922453; WOS: 000952386100001
    • الرقم المعرف:
      10.1111/exd.14788
    • Rights:
      http://creativecommons.org/licenses/by-nc-nd/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.92E33A7C