Contributors: Aprea, Maria Grazia; Schiavetti, Irene; Portaccio, Emilio; Ballerini, Chiara; Battaglia, Mario Alberto; Bergamaschi, Roberto; Brichetto, Giampaolo; Bunul, S Destan; Calabrese, Massimiliano; Capobianco, Marco; Cavalla, Paola; Celani, Maria Grazia; Clerico, Marinella; Cocco, Eleonora; Comi, Giancarlo; Confalonieri, Paolo; Conte, Antonella; Cordioli, Cinzia; De Luca, Giovanna; De Rossi, Nicola; Filippi, Massimo; Gumes, Haluk; Immovilli, Paolo; Inglese, Matilde; Karabudak, Rana; Landi, Doriana; Lanzillo, Roberta; L'Episcopo, Maria Rita; Lorefice, Lorena; Mantero, Vittorio; Marangoni, Sabrina; Marfia, Girolama Alessandra; Masciulli, Camilla; Milano, Eva; Moiola, Lucia; Orlandi, Riccardo; Patti, Francesco; Perini, Paola; Pesci, Ilaria; Pucci, Eugenio; Puthenparampil, Marco; Radaelli, Marta; Salvetti, Marco; Sartori, Arianna; Scandellari, Cinzia; Sen, Sedat; Siva, Aksel; Strumia, Silvia; Teatini, Francesco; Tedeschi, Gioacchino; Trojano, Maria; Tutuncu, Melih; Vaula, Giovanna; Sormani, Maria Pia; Amato, Maria Pia
نبذة مختصرة : Background: In the general population, maternal SARS-CoV-2 infection during pregnancy is associated with worse maternal outcomes; however, only one study so far has evaluated COVID-19 clinical outcomes in pregnant and postpartum women with multiple sclerosis, showing no higher risk for poor COVID-19 outcomes in these patients. Objective: In this multicenter study, we aimed to evaluate COVID-19 clinical outcomes in pregnant patients with multiple sclerosis. Methods: We recruited 85 pregnant patients with multiple sclerosis who contracted COVID-19 after conception and were prospectively followed-up in Italian and Turkish Centers, in the period 2020-2022. A control group of 1354 women was extracted from the database of the Multiple Sclerosis and COVID-19 (MuSC-19). Univariate and subsequent logistic regression models were fitted to search for risk factors associated with severe COVID-19 course (at least one outcome among hospitalization, intensive care unit [ICU] admission and death). Results: In the multivariable analysis, independent predictors of severe COVID-19 were age, body mass index ⩾ 30, treatment with anti-CD20 and recent use of methylprednisolone. Vaccination before infection was a protective factor. Vaccination before infection was a protective factor. Pregnancy was not a risk nor a protective factor for severe COVID-19 course. Conclusion: Our data show no significant increase of severe COVID-19 outcomes in patients with multiple sclerosis who contracted the infection during pregnancy.
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