Contributors: Rodriguez-Ayllon,M; Esteban-Cornejo,I; Mora-Gonzalez,J; Cadenas-Sanchez,C; Plaza-Florido,A; Molina-Garcia,P; Ortega,FB PROFITH “Promoting Fitness and Health Through Physical Activity” Research Group, Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain. Verdejo-Román,J; Catena,A The Brain, Mind and Behavior Research Center, University of Granada (CIMCYC-UGR), Granada, Spain. Verdejo-Román,J Laboratory of Cognitive and Computational Neuroscience (UCM‑UPM), Centre for Biomedical Technology (CTB), Madrid, Spain. Muetzel,RL Department of Child and Adolescent Psychiatry, Erasmus MC – Sophia Children’s Hospital, Rotterdam, The Netherlands. Muetzel,RL Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands. Mora-Gonzalez,J College of Health and Human Services, University of North Carolina at Charlotte, Charlotte, NC, USA. Cadenas-Sanchez,C MOVE‑IT Research Group and Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain. Cadenas-Sanchez,C Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain. Kramer,AF Center for Cognitive and Brain Health, Department of Psychology, Northeastern University, Boston, MA, USA. Kramer,AF Beckman Institute, University of Illinois at Urbana-Champaign, IL, USA. Catena,A Department of Clinical Psychology, University of Granada, Granada, Spain. Ortega,FB Department of Biosciences and Nutrition, Karolinska Institutet, Group MLO, Huddinge, Sweden.; This work study was supported by the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP), the European Regional Development Fund (ERDF)”, the European Commission (No 667302), and the Alicia Koplowitz Foundation. Tis study was partially funded by the University of Granada, Research and Knowledge Transfer Fund (PPIT) 2016, the Excellence Actions Programme: Units of Excellence; Scientifc Unit of Excellence on Exercise and Health (UCEES), the Andalusian Regional Government, the Regional Ministry of Economy, Knowledge, Entreprises and University, and the European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR. IE-C is supported by the Spanish Ministry of Economy and Competitiveness (RTI2018-095284-J-100). In addition, this study was further supported by the SAMID III network, RETICS, funded by the PN I+D+I 2017-2021 (Spain). JM-G and AP-F are supported by the Spanish Ministry of Education, Culture and Sport (FPU14/06837, FPU 16/02760, respectively). CC-S is supported by the Government of Andalusian, Integrated Territorial Initiative 2014-2020 for the province of Cádiz (PI-0002-2017). JVR is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396).
نبذة مختصرة : Recent studies investigated the association of cardiorespiratory fitness with white matter microstructure in children, yet little work has explored to what extent other components of physical fitness (i.e., muscular or motor fitness) are associated with white matter microstructure. Indeed, this association has not been previously explored in children with overweight/obesity who present a different white matter development. Therefore, we aimed to examine associations between physical fitness components and white matter microstructure in children with overweight/obesity. In total, 104 (10.04 ± 1.15 years old; 43 girls) children were included in this cross-sectional study. Physical fitness was assessed using the ALPHA-fitness test battery. Fractional anisotropy (FA) and mean diffusivity were derived from diffusion tensor imaging (DTI). No association was found between physical fitness and global DTI metrics (all P > 0.082). Within individual tracts, all associations became non-significant when analyses were adjusted for multiple comparisons. Using the voxel-wise approach, we identified a small cluster in the left lateral frontal lobe where children with greater upper-body muscular fitness showed higher FA (PFWE-corrected = 0.042). Although our results cannot conclude physical fitness is related to white matter microstructure in children with overweight/obesity; those findings indicate that the association of muscular fitness with white matter microstructure might be more focal on frontal areas of the brain, as opposed to global differences. ; Yes
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