Long term complications in survivors of neuroblastoma, study of a French regional cohort ; Complications à long terme chez les patients traités pour un neuroblastome dans l’enfance, étude d’une cohorte régionale française

Background. Neuroblastoma is a childhood cancer treated with surgery or multimodal therapy including chemotherapy and radiations. Long term complications can occur many years after treatment. The aim of this study was to describe physical long-term sequelae for adult neuroblastoma survivors and to evaluate their correlation with treatment. Methods. A prospective multicentric regional study was conducted to evaluate long-term complications for all childhood cancer survivors in Rhone-Alpes Region. 40 neuroblastoma survivors treated between 1987 and 1999 were seen in long term follow-up clinical consultation. Results. The median follow-up was 20.5 years (range 16.9-25.7). Received treatments were surgery alone for 13 patients, surgery and standard chemotherapy for 21 patients and multimodal intensive therapy for 6 patients. A total of 94 physical long-term complications were observed in 32 patients (80%) with a median of 2 per patient (range 0-9). The main long-term complications were metabolism disorder (42.5%), neurological impairment (32.5%), musculoskeletal impairment (27.5%), hearing loss (20%) and endocrine complications (17.5%). The number of sequelae increased after multimodal intensive therapy (p < 0.0001), as well as their severity (p < 0.0001). Psychiatric disorders were found in 52.9% of patients. Conclusion. A large proportion of patients treated for neuroblastoma in childhood experience long term complications, especially after an intensive treatment. This underscores the need for long term follow-up for childhood cancer survivors. ; Contexte. Le neuroblastome est un cancer pédiatrique traité par chirurgie seule qui peut être associée à une chimiothérapie standard ou haute dose, ou une radiothérapie en fonction du niveau de risque de la maladie. Des complications à long terme peuvent survenir, y compris plusieurs années après le traitement. Notre objectif était de décrire les séquelles à long terme chez des adultes survivants d’un neuroblastome et d’évaluer leur corrélation avec le traitement ...