بيانات النشر: Linköpings universitet, Avdelningen för diagnostik och specialistmedicin
Linköpings universitet, Medicinska fakulteten
Region Östergötland, Fysiologiska kliniken US
Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV
Region Östergötland, Lungmedicinska kliniken US
Linköpings universitet, Avdelningen för prevention, rehabilitering och nära vård
Region Östergötland, Vårdcentralen Ekholmen
Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
Univ Gothenburg, Sweden
Umea Univ, Sweden
Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden
Karolinska Inst, Sweden
Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
Lund Univ, Sweden; Skane Univ Hosp, Sweden
Uppsala Univ, Sweden
Karolinska Inst, Sweden; Karolinska Univ Hosp Solna, Sweden
Lund Univ, Sweden
Sahlgrens Univ Hosp, Sweden; Gothenburg Univ, Sweden
Karolinska Univ Hosp Solna, Sweden; Karolinska Inst, Sweden; Karolinska Inst, Sweden
WILEY
نبذة مختصرة : Chronic airflow limitation (CAL) can be defined as fixed ratio of forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) any respiratory symptom. In a cross-sectional general population study, 15,128 adults (50-64 years of age), 7,120 never-smokers and 8,008 ever-smokers completed a respiratory questionnaire and performed FEV1 and FVC after bronchodilation. We calculated different ratios of FEV1/FVC from 0.40 to 1.0 using 0.70 as reference category. We analysed odds ratios (OR) between different ratios and any respiratory symptom using adjusted multivariable logistic regression. Among all subjects, regardless of smoking habits, the lowest odds for any respiratory symptom was at FEV1/FVC = 0.82, OR 0.48 (95% CI 0.41-0.56). Among never-smokers, the lowest odds for any respiratory symptom was at FEV1/FVC = 0.81, OR 0.53 (95% CI 0.41-0.70). Among ever-smokers, the odds for any respiratory symptom was lowest at FEV1/FVC = 0.81, OR 0.43 (95% CI 0.16-1.19), although the rate of inclining in odds was small in the upper part, that is FEV1/FVC = 0.85 showed similar odds, OR 0.45 (95% CI 0.38-0.55). We concluded that the odds for any respiratory symptoms continuously decreased with higher FEV1/FVC ratios and reached a minimum around 0.80-0.85, with similar results among never-smokers. These results indicate that the optimal threshold associated with respiratory symptoms may be higher than 0.70 and this should be further investigated in prospective longitudinal studies. ; Funding Agencies|Knut och Alice Wallenbergs StiftelseKnut & Alice Wallenberg Foundation; Forskningsradet om Halsa, Arbetsliv och Valfard; VetenskapsradetSwedish Research Council; Hjart-Lungfonden; Swedish State ALF Agreement; VINNOVAVinnova
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