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Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

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  • معلومة اضافية
    • Contributors:
      The Wellcome Trust Centre for Human Genetics Oxford; University of Oxford; London School of Hygiene and Tropical Medicine (LSHTM); The Wellcome Trust Sanger Institute Cambridge; St Mary's Hospital, Imperial College; TNW and MM are funded through awards from the Wellcome Trust (grants 091758 and 202800 to TNW and grant 088634 to MM ) and DPK and TGC receive support from the Medical Research Council (grant G19/9 to DPK and grants MR/K000551/1, MR/M01360X/1, MR/N010469/1, and MC_PC_15103 to TGC ). The research leading to these results received funding from the European Community's Seventh Framework Programme (FP7/2007-2013, under grant agreement 242095) and from the Medical Research Council (grant G0600718). MalariaGEN is supported by the Wellcome Trust (WT077383/Z/05/Z) and by the Foundation for the National Institutes of Health (grant 566) as part of the Bill & Melinda Gates' Grand Challenges in Global Health Initiative. The Resource Centre for Genomic Epidemiology of Malaria is supported by the Wellcome Trust (grant 090770/Z/09/Z). Support was also provided by the Medical Research Council (grant G0600718). The Wellcome Trust also provides core awards to the Wellcome Trust Centre for Human Genetics (grant 090532/Z/09/Z) and to the Wellcome Trust Sanger Institute (grant 098051). This work forms part of a larger collaboration with the MalariaGEN Consortium, whose members are listed at http://www.malariagen.net/projects/host/consortium-members. This paper is published with permission from the Director of the Kenya Medical Research Institute (KEMRI).; MalariaGEN Consortium (Anavaj Sakuntabhai); European Project: 242095,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,EVIMALAR(2009)
    • بيانات النشر:
      HAL CCSD
      Elsevier
    • الموضوع:
      2018
    • Collection:
      Institut Pasteur: HAL
    • نبذة مختصرة :
      International audience ; Background Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/30033078; info:eu-repo/grantAgreement/EC/FP7/242095/EU/Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR)./EVIMALAR; pasteur-02084676; https://hal-pasteur.archives-ouvertes.fr/pasteur-02084676; https://hal-pasteur.archives-ouvertes.fr/pasteur-02084676/document; https://hal-pasteur.archives-ouvertes.fr/pasteur-02084676/file/1-s2.0-S2352302618301078-main.pdf; PUBMED: 30033078
    • الرقم المعرف:
      10.1016/S2352-3026(18)30107-8
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.90BFBCB4