Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      MDPI
    • الموضوع:
      2021
    • Collection:
      Universidade of Minho: RepositóriUM
    • نبذة مختصرة :
      Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a doseeffect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration. ; The authors acknowledge Classius Ferreira da Silva, from the Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, for the scanning electron microscopy analyses. ; info:eu-repo/semantics/publishedVersion
    • File Description:
      application/pdf
    • ISSN:
      2305-6304
    • Relation:
      https://www.mdpi.com/2305-6304/9/8/173; Neto, Conrado M. S.; Lima, Felipe C.; Morais, Renata P.; de Andrade, Lucas R. M.; de Lima, Renata; Chaud, Marco V.; Pereira, Matheus M.; de Albuquerque Júnior, Ricardo L. C.; Cardoso, Juliana C.; Zielinska, Aleksandra; Souto, Eliana; Lima, Álvaro S.; Severino, Patrícia, Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts. Toxics, 9(8), 173, 2021; http://hdl.handle.net/1822/73775
    • الرقم المعرف:
      10.3390/toxics9080173
    • الدخول الالكتروني :
      http://hdl.handle.net/1822/73775
      https://doi.org/10.3390/toxics9080173
    • Rights:
      info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/
    • الرقم المعرف:
      edsbas.8F6F00BE