Tissue Factor is an Angiogenic Mediator that Induces both Vascular Endothelial Growth Factor (VEGF) and Basic Fibroblast Growth Factor (bFGF)

factor (bFGF) Acute myeloid leukemia (AML) is a biologically hetero-geneous disease of the hematopoietic system characterized by a block in differentiation of immature blast cells in bone marrow. Recent studies suggest that angiogenesis in bone marrow plays a critical role in leukemogenesis and thus antiangiogenic strategies are considered for the treatment of AML. 1 Angiogenesis, the process of new blood vessels from pre-existing vessels, plays an important role in various physiological and pathological conditions. Angiogenesis in physiological processes is involved in embryonic development, growth, and wound healing. The process is a multi-step mechanism that encompasses activation, migration, and