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Consistent trajectories of rhinitis control and treatment in 16,177 weeks : the MASK-air® longitudinal study

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  • معلومة اضافية
    • بيانات النشر:
      Umeå universitet, Institutionen för datavetenskap
      MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, Portugal
      Department of Health Research Methods, Evidence, and Impact & Department of Medicine, McMaster University, ON, Hamilton, Canada
      ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
      Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany; Center for Rhinology and Allergology, Wiesbaden, Germany
      Medical Consulting Czarlewski, Levallois, France
      Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain
      Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
      ARIA, Montpellier, France
      Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino & Mauriziano Hospital, Torino, Italy
      Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Institute of Clinical medicine, Clinic of Chest diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
      Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
      Chiba University Hospital and Chiba Rosai Hospital, Chiba, Japan
      Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy
      Transylvania University Brasov, Brasov, Romania
      Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain
      Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany
      Quality Use of Respiratory Medicine Group, Woolcock Institute of Medical Research, The University of Sydney and Sydney Local Health District, NSW, Sydney, Australia
      Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy
      Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL research network, Barcelona, Spain
      Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal; NOVA Medical School/Comprehensive Health Research Centre (CHRC), Lisbon, Portugal
      Division of Allergy/immunology, University of South Florida, FL, Tampa, United States
      SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy
      School of Medicine, University CEU San Pablo, Madrid, Spain
      ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey
      UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal
      Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Brazil
      Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy
      VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France
      Department of Otorhinolaryngology, Amsterdam University Medical Centres, location AMC, Amsterdam, Netherlands
      Department of Pulmonary Diseases, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey
      Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
      Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina
      Kazakhstan Association of Allergology and Clinical Immunology, Department of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan
      Department of Clinical Immunology, Wrocław Medical University, and ALL-MED Medical Research Institute, Wroclaw, Poland
      Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
      Poltava State Medical University, Poltava, Ukraine
      Laboratory of Molecular immunology, National Research Center, Institute of Immunology, Federal Medicobiological Agency, Moscow, Russian Federation; Pirogov Russian National Research Medical University, Moscow, Russian Federation
      Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary
      KYomed INNOV, Montpellier, France
      Scottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, United Kingdom
      Department of Pulmonary Medicine, CHU Liège and GIGA I3 research group, University of Liège, Liege, Belgium
      Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, "Attikon" University Hospital, National & Kapodistrian University of Athens, Athens, Greece
      Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
      Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal
      IMSB, Medical Faculty, University at Cologne, and ClinCompetence Cologne GmbH, Cologne, Germany
      Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
      Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
      Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Battipaglia and Agency of Health ASL, Salerno, Italy
      Ecole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des Armées), Bretigny, France
      Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal; Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal
      Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, Netherlands
      Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon; Department of Otorhinolaryngology-Head and Neck Surgery, Dar Al Shifa Hospital, Salmiya, Kuwait
      Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland
      Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom
      Department of Respiratory Medicine and Tuberculosis, University Hospital, Brno, Czech Republic
      Imunoalergologia, Centro Hospitalar Universitário de Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
      CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal; UBIAir - Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã, Portugal; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal
      Fundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Madrid, Spain
      Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Iraklio, Greece; International Primary Care Respiratory Group IPCRG, Aberdeen, United Kingdom
      Institute of Clinical Medicine and Institute of Health Sciences, Vilnius and Medical Faculty of Vilnius University, Vilnius, Lithuania
      Department of Chest Medicine, Centre Hospitalier Universitaire UCL, Namur, and Université Catholique de Louvain, Yvoir, Belgium
      Nova Southeastern University, FL, Fort Lauderdale, United States
      Department of Medicine, Clinical Immunology and Allergy, McMaster University, ON, Hamilton, Canada
      Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
      University Clinic of Respiratory and Allergic Diseases, Golnick, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
      Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany; University Hospital Montpellier, Montpellier, France
    • الموضوع:
      2023
    • Collection:
      Umeå University: Publications (DiVA)
    • نبذة مختصرة :
      Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air® data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7 days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age ± SD = 39.1 ± 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms.
    • File Description:
      application/pdf
    • Relation:
      Allergy. European Journal of Allergy and Clinical Immunology, 0105-4538, 2023, 78:4, s. 968-983; orcid:0000-0003-3965-2834; http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201742; PMID 36325824; ISI:000898446700001; Scopus 2-s2.0-85143420123
    • الرقم المعرف:
      10.1111/all.15574
    • Rights:
      info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.8F24837D