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Inhibitory effects of quinidine on rat heart muscarinic receptors

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • الموضوع:
      1984
    • Collection:
      DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB)
    • نبذة مختصرة :
      Quinidine inhibited binding of the labelled agonist [3H]oxotremorine M ([3HOxo-M) and the labelled antagonist [3H]N-methylscopolamine ([3H]NMS) to rat heart muscarinic receptors. Kinetic studies demonstrated that quinidine decreased the association rates (I50: 4 and 7.5 μM) and dissociation rates (I50: 100 and 68 μM) of [3H]Oxo-M and [3H]NMS, with different potencies. These cooperative effects explained the low Hill coefficients and apparent selectivity of quinidine competition curves. ; SCOPUS: ar.j ; info:eu-repo/semantics/published
    • File Description:
      2 full-text file(s): application/pdf | application/pdf
    • Relation:
      uri/info:doi/10.1016/0024-3205(84)90071-7; uri/info:pii/0024-3205(84)90071-7; uri/info:pmid/6482646; uri/info:scp/0021266466; local/VX-015863; https://dipot.ulb.ac.be/dspace/bitstream/2013/83940/4/Elsevier_62108.pdf; https://dipot.ulb.ac.be/dspace/bitstream/2013/83940/7/318d5b8a-a108-4ddf-a366-5bf40ed33b80.txt; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/83940
    • الرقم المعرف:
      edsbas.8BDAE072