نبذة مختصرة : Quinidine inhibited binding of the labelled agonist [3H]oxotremorine M ([3HOxo-M) and the labelled antagonist [3H]N-methylscopolamine ([3H]NMS) to rat heart muscarinic receptors. Kinetic studies demonstrated that quinidine decreased the association rates (I50: 4 and 7.5 μM) and dissociation rates (I50: 100 and 68 μM) of [3H]Oxo-M and [3H]NMS, with different potencies. These cooperative effects explained the low Hill coefficients and apparent selectivity of quinidine competition curves. ; SCOPUS: ar.j ; info:eu-repo/semantics/published
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