Construction and characterization of Fe 3 O 4 @BAAH-CuCl nanomagnetic catalyst: catalysis research in synthesis of 2-aryl quinazolines from prepared benzylamines ...

We have constructed Fe 3 O 4 @BAAH-CuCl nanomagnetic catalyst in ChCl-Urea (choline chloride deep eutectic as solvent) as a highly efficient catalytic system for the preparation of 2-aryl quinazoline derivatives through one-pot, three-component reactions of 2-bromobenzaldehyde with primary amines and sodium azide under molecular oxygen. FT-IR, VSM, SEM, TEM, TGA, XRD, EDX, ICP-OES and elemental mapping analyses confirmed the fabrication of Fe 3 O 4 @BAAH-CuCl nanomaterial. In this project, we first prepared various derivatives of benzylamines from reduction of aryl nitriles, then used the benzylamine products as substrates in the three-component synthesis of 2-aryl quinazoline derivatives in the presence of Fe 3 O 4 @BAAH-CuCl/ChCl-Urea as an efficient catalytic system. Although the synthesized products (primary amines and 2-aryl quinazolines) were known, their physical state was confirmed with the reported samples in the literature and the structure of all the products confirmed by 1 HNMR and 1 CNMR. ...