Contribution of rotational thromboelastometry for the diagnostic assessment of hemostatic disorders in dogs : application to leptospirosis ; Apports de la thromboélastométrie rotative dans l’exploration des désordres de l’hémostase chez le chien : application à la leptospirose

Rotational thromboelastometry (TEM) can be used to assess the viscoelastic properties of clot formation in whole blood under low shear conditions, which provides information on global hemostatic function from the beginning of clot formation through fibrinolysis. The shape of the TEM profile defines a patient’s hemostatic condition as normal, hypercoagulable, or hypocoagulable. First, the studies of this work emphasize that sex and neutered status does not affect the values of TEM parameters. The second study demonstrated an age-related hypercoagulable profile that was associated with decreased fibrinolysis ability in healthy Beagles. Low-grade inflammation seemed to be involved in this process. The incidence of thromboembolic diseases remains to be established in old dogs, but age should be considered a primary risk factor. Third, TEM is insensitive to detect the biological activities of a particular low molecular weight heparin, sodium enoxaparin, in healthy Beagles. Finally, TEM is useful for the description of hemostatic disorders in dogs with naturally occurring leptospirosis. A hypocoagulable profile is associated with bleeding diatheses and the measured TEM parameters are significantly different between dogs with and without disseminated intravascular coagulation. Some measured TEM parameters and calculated indices are associated with outcomes: a hypocoagulable profile is correlated with a higher mortality rate ; La thromboélastométrie (TEM) rotative est un examen évaluant les propriétés viscoélastiques du sang dans des conditions de faible cisaillement. La TEM est capable d'apprécier dynamiquement la fonction hémostatique globale d'un patient depuis la formation du caillot à sa lyse. Le profil obtenu par cette technique peut être classé en hypercoagulable, normal ou hypocoagulable. Les études de ce travail révèlent que le sexe et la stérilisation n'affectent pas la valeur des différents paramètres TEM. L'âge est associé à l'apparition de profils hypercoagulables et à une diminution de l'activité ...