Neurocognitive Correlates of Cognitive Behavioral Therapy (CBT) in Children and Adolescents with Obsessive-Compulsive Disorder (OCD) - a Sub-Study to the 'TECTO' Randomized Controlled Trial ...

Background and aims: Atypical neurocognitive functioning has been found in children with obsessive-compulsive disorder (OCD) and is proposed a possible moderator and/or mediator of the symptom-reduction following psychotherapy. The recommended first-line treatment for pediatric OCD is cognitive-behavioral therapy (CBT) with exposure and response prevention (ERP). This study aims to investigate neurocognitive correlates of family-based CBT (F-CBT) with ERP in children with OCD. The study is nested in the Danish superiority randomized controlled trial (RCT) “TECTO”, which assesses benefits and harms of 14 sessions of F-CBT with ERP, compared to an active control intervention of psychoeducation and relaxation therapy (PRT), in children and adolescents (age 8-17) with OCD. Clinical assessment: OCD symptom-reduction following therapy (the primary outcome of the TECTO-trial) is measured with the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) total score. Neurocognitive assessment: Neurocognitive status ...