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Epidemiological Survey of Patients With Hemodialysis Complicated by Hepatitis C in Japan

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  • معلومة اضافية
    • بيانات النشر:
      Wiley
    • الموضوع:
      2018
    • Collection:
      Wiley Online Library (Open Access Articles via Crossref)
    • نبذة مختصرة :
      Nowadays, interferon‐free direct‐acting antiviral (DAA) treatment is the standard of care for chronic hepatitis C patients. Some DAA regimens are highly effective and safe even for those with renal dysfunction/failure including those receiving HD. However, it remains unclear to what extent HD specialists gain knowledge about advances in anti‐hepatitis C virus (HCV) treatment. To clarify the current situation and identify problems in the treatment of HD patients with chronic hepatitis C, we performed a questionnaire survey at 36 HD facilities between June 2016 and September 2017. In a total of 3418 HD patients, 179 (5.2%) were positive for anti‐HCV antibody, and among these patients, 110/125 (88.0%) were positive for serum HCV RNA. Of the latter, only 42/110 (38.2%) patients received antiviral therapy. Moreover, HCV serotyping or genotyping was performed in 23/110 (20.9%) patients. In 26/49 (53.1%) of the remaining 68 untreated patients, “HD specialists do not know any HCV‐specific treatments” and “HD specialists have no opportunity to consult with a hepatologist” were the reasons cited for the lack of anti‐HCV treatment. This epidemiological study found that some HD patients with chronic hepatitis C had not yet received antiviral treatment despite the emergence of DAAs. To overcome such undesirable circumstances, medical cooperation between HD specialists and hepatologists should be required.
    • الرقم المعرف:
      10.1111/1744-9987.12747
    • الدخول الالكتروني :
      http://dx.doi.org/10.1111/1744-9987.12747
      https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2F1744-9987.12747
      https://onlinelibrary.wiley.com/doi/pdf/10.1111/1744-9987.12747
    • Rights:
      http://onlinelibrary.wiley.com/termsAndConditions#vor
    • الرقم المعرف:
      edsbas.823EB7A8