Flow Chemistry Processes for the Catalytic Functionalisation of Biomass Derivative ; Procédés de chimie en flux pour la fonctionnalisation catalytique de dérivés de la biomasse

In order to move towards a more sustainable synthetic chemistry, it is now necessary to synthesize intermediates and high value-added products from biomass substrates rather than from fossil resources. Furthermore, the valorization of agricultural waste is one of the keystones of a circular economy. In this sense, furfural has been listed as a promising platform that can be obtained from food crop residues and wood industry waste. Indeed, the dehydration of lignocellulose from these agricultural wastes gives access to furanic derivatives. Their selective functionalization is currently an emerging field and is the subject of many research efforts. In particular, the activation and direct functionalization of C–H bonds catalyzed by transition metals has become essential to develop step and atom economical syntheses. Moreover, the use of heterogeneous catalysts for this purpose is more in line with the principles of a greener chemistry by allowing, in addition to the easy recycling of the used catalyst, a better purification of the obtained product. Furthermore, the combination of heterogeneous catalysis with flow chemistry technology offers a very powerful tool for large-scale applications. In this manuscript, we report the C3-functionalization of furfurylimines by homogeneous ruthenium catalysis in continuous flow. Then, the heterogenization of ruthenium and palladium catalysts was studied in order to develop functionalizations in heterogeneous flow catalysis of furfural derivatives. In this direction, promising results have been obtained for the C5-arylation of furfural with a palladium catalyst supported on mesoporous silica and a continuous flow application has been successfully developped. ; Afin d’évoluer vers une chimie de synthèse plus durable, il est aujourd’hui nécessaire de synthétiser des intermédiaires et des produits à haute valeur ajoutée à partir de substrats provenant de la biomasse plutôt que de ressources fossiles. En outre, la valorisation des déchets agricoles est l’une des clés de voûte d’une ...