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Effectiveness of malaria control interventions in Madagascar: a nationwide case-control survey

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  • معلومة اضافية
    • Contributors:
      Institut Pasteur de Madagascar; Réseau International des Instituts Pasteur (RIIP); Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE); Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE); Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48; INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48; INSB-INSB-Centre National de la Recherche Scientifique (CNRS); Fondation Mérieux; Unité d'Epidémiologie Antananarivo, Madagascar (IPM); Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP); Institut de Recherche Biomédicale des Armées (IRBA); This research was supported by the Global Fund to Fight AIDS, Tuberculosis and Malaria via the Initiative 5 % programme initiated by the French Ministry of Foreign Affairs and France Expertise Internationale (Grant #12INI109).; ANR-05-PADD-0012,PRODDIG,Promotion du Développement Durable par les Indications Géographiques(2005)
    • بيانات النشر:
      HAL CCSD
      BioMed Central
    • الموضوع:
      2016
    • Collection:
      Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe)
    • نبذة مختصرة :
      International audience ; BACKGROUND:Madagascar, as other malaria endemic countries, depends mainly on international funding for the implementation of malaria control interventions (MCI). As these funds no longer increase, policy makers need to know whether these MCI actually provide the expected protection. This study aimed at measuring the effectiveness of MCI deployed in all transmission patterns of Madagascar in 2012-2013 against the occurrence of clinical malaria cases.METHODS:From September 2012 to August 2013, patients consulting for non-complicated malaria in 31 sentinel health centres (SHC) were asked to answer a short questionnaire about long-lasting insecticidal nets (LLIN) use, indoor residual spraying (IRS) in the household and intermittent preventive treatment of pregnant women (IPTp) intake. Controls were healthy all-ages individuals sampled from a concurrent cross-sectional survey conducted in areas surrounding the SHC. Cases and controls were retained in the database if they were resident of the same communes. The association between Plasmodium infection and exposure to MCI was calculated by multivariate multilevel models, and the protective effectiveness (PE) of an intervention was defined as 1 minus the odds ratio of this association.RESULTS:Data about 841 cases (out of 6760 cases observed in SHC) and 8284 controls was collected. The regular use of LLIN provided a significant 51 % PE (95 % CI [16-71]) in multivariate analysis, excluding in one transmission pattern where PE was -11 % (95 % CI [-251 to 65]) in univariate analysis. The PE of IRS was 51 % (95 % CI [31-65]), and the PE of exposure to both regular use of LLIN and IRS was 72 % (95 % CI [28-89]) in multivariate analyses. Vector control interventions avoided yearly over 100,000 clinical cases of malaria in Madagascar. The maternal PE of IPTp was 73 %.CONCLUSIONS:In Madagascar, LLIN and IRS had good PE against clinical malaria. These results may apply to other countries with similar transmission profiles, but such case-control surveys ...
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/26867661; pasteur-01952731; https://hal-riip.archives-ouvertes.fr/pasteur-01952731; https://hal-riip.archives-ouvertes.fr/pasteur-01952731/document; https://hal-riip.archives-ouvertes.fr/pasteur-01952731/file/13_Effectiveness%20of%20malaria%20control%20interventions%20in%20Madagascar.pdf; PUBMED: 26867661; PUBMEDCENTRAL: PMC4751752
    • الرقم المعرف:
      10.1186/s12936-016-1132-x
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.7CE96CD3