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Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Department of Public Health and Infectious Diseases; Università degli Studi di Roma "La Sapienza" = Sapienza University Rome -Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP); Università cattolica del Sacro Cuore Roma (Unicatt); Fondazione “Policlinico Universitario A. Gemelli” Rome; Institut NeuroMyoGène (INMG); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM); IRCCS Ospedale San Raffaele Milan, Italy; Institute of Translational Pharmacology - Istituto di Farmacologia Traslazionale Roma (IFT); Consiglio Nazionale delle Ricerche Roma (CNR); This work was supported by the following grants from the Italian Ministry of Instruction, University and Research: PRIN #20179JHMZ_006 and #2015W729WH_005 to G.D.C.; #2015W729WH_001 to A.T.P.; #2017A9MK4R_004 to C.G.; by the French National Research Agency (ANR-18-CE15-0014-01, EPIPRO project) to P.L.; and by Ateneo 2019 (prot. RP11916B8696E5EC) to M.E.M.; ANR-18-CE15-0014,EPIPRO,Epigénétique de la persistance virale induite par l'association du virus HSV-­1 latent avec les corps nucléaires PML(2018)
    • بيانات النشر:
      HAL CCSD
      Elsevier
    • الموضوع:
      2020
    • Collection:
      Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe)
    • نبذة مختصرة :
      International audience ; Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus, which spreads and then actively replicates to the site of primary infection (usually the lips or eyes). Viral particles produced following reactivation can also reach the brain, causing a rare but severe form of diffuse acute infection, namely herpes simplex encephalitis. Most of the time, this infection is clinically asymptomatic. However, it was recently correlated with the production and accumulation of neuropathological biomarkers of Alzheimer’s disease. In this review we discuss the different cellular and molecular mechanisms underlying the acute and long-term damage caused by HSV-1 infection in the brain.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/32386801; hal-03043678; https://hal.archives-ouvertes.fr/hal-03043678; https://hal.archives-ouvertes.fr/hal-03043678/document; https://hal.archives-ouvertes.fr/hal-03043678/file/26%20Marcocci%20et%20al-2020-TIM.pdf; PUBMED: 32386801
    • الرقم المعرف:
      10.1016/j.tim.2020.03.003
    • Rights:
      http://creativecommons.org/licenses/by-nc-nd/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.7AFEF508