Morphological Features of Pregnancy of Uterine Leiomyomas

Introduction/ Background According to numerous publications of diseases among women of reproductive age, uterine leiomyoma are in the second place in the structure of gynecological pathology. Uterine leiomyoma - a benign, well-encapsulated tumor limitation, the source of which are the smooth muscle cells of the body of the uterus or cervix. According to different authors, in 0,4-3,9% of cases, the presence of tumor is diagnosed during pregnancy. Presence of myomas nodes leads to the threat of termination of pregnancy, missed abortion, the threat of fetal hypoxia, early and late gestosis, bleeding during pregnancy and childbirth . Moreover, the nature of complications depends on the size and morphological features of tumor’s myoma nodes. Aims To study the morphological features of leiomyomas during pregnancy given the size of tumors and secondary changes in it. Methods Morphological examination of myomas was conducted in 25 cases of pregnancies completed caesarean section in 36-39 weeks of gestation with subsequent enucleation nodes. All myomas were divided into 2 groups: a core group of 10 nodes (more than 5 cm) and a control group of 15 nodes (less than 5 cm). On gross examination of tumors taken into consideration the number, size, texture, color, structure and the presence of degenerative changes. In each case of leyomioma nodes excised tissue portions from the central zone and the edge of the paracentral. The fragments of tissue were fixed in neutral formalin, followed by pouring into paraffin. With each produced histological preparations stained hematoxylin and eosin, and van Gieson’s stain. Microscopic investigations were conducted on increasing × 100 × 400 with a microscope Primo Star (Carl Zeiss, Germany). Results At external examination of uterine control group were tightly-elastic and dense consistency. In the main group was uneven consistency of nodes, with the presence of foci of softening. In the main group tumor size reached 5.0 cm to 17.0 cm in diameter, these nodes along with portions of white or ...