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Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder

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  • معلومة اضافية
    • Contributors:
      Department of Psychiatry; HUS Psychiatry; University of Helsinki; Clinicum; Institute for Molecular Medicine Finland; Genomics of Neurological and Neuropsychiatric Disorders; Staff Services; Centre of Excellence in Complex Disease Genetics; Research Programme of Molecular Medicine; Aarno Palotie / Principal Investigator
    • بيانات النشر:
      MDPI AG
    • الموضوع:
      2021
    • Collection:
      Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto
    • نبذة مختصرة :
      The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder. ; Peer reviewed
    • File Description:
      application/pdf
    • Relation:
      The work was supported by a grant from the Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA (grant agreement nos. 6045290-5500000710 and 6000009-5500000710). The principal author was supported by the H2020 Marie Sklodowska-Curie Actions co-funding of regional, national, and international programs (COFUND) (grant agreement no. 713606) for his doctoral program (MSC-COFUND, I4FUTURE). The principal author was also supported by the Iso-Maellisen Foundation (Iso-Maellisen Saeaetioe) through a medical grant of EUR 4000 for the year 2019 (grant no. 0400 584622).; Mazumder , A H , Barnett , J , Isometsä , E T , Lindberg , N , Torniainen-Holm , M , Lähteenvuo , M , Lahdensuo , K , Kerkelä , M , Ahola-Olli , A , Hietala , J , Kampman , O , Kieseppä , T , Jukuri , T , Häkkinen , K , Cederlöf , E , Haaki , W , Kajanne , R , Wegelius , A , Männynsalo , T , Niemi-Pynttäri , J , Suokas , K , Lönnqvist , J , Tiihonen , J , Paunio , T , Vainio , S J , Palotie , A , Niemelä , S , Suvisaari , J & Veijola , J 2021 , ' Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder ' , Brain Sciences , vol. 11 , no. 11 , 1422 . https://doi.org/10.3390/brainsci11111422; ORCID: /0000-0002-2527-5874/work/104884847; ORCID: /0000-0001-5956-2399/work/107239209; ORCID: /0000-0001-6296-6343/work/162189186; http://hdl.handle.net/10138/337721; e79069fe-de71-4140-bdcb-477f8f06c300; 000725104400001
    • الدخول الالكتروني :
      http://hdl.handle.net/10138/337721
    • Rights:
      cc_by ; info:eu-repo/semantics/openAccess ; openAccess
    • الرقم المعرف:
      edsbas.7675D9FB