Pengaruh Puasa 12 Jam Terhadap Kadar Glukosa Darah Puasa dan Berat Badan Pada Mencit (Mus Musculus) Hiperglikemia Induksi Aloksan

The term "hyperglycemia" comes from the Greek words hyper (high), glykys (sweet/sugar) and haima (blood). Insulin deficiency, or the inability of cells to respond to insulin, causes high blood sugar levels (hyperglycemia), which is a clinical sign of diabetes. Diabetes, is a serious, long-term (or "chronic") condition that occurs when blood sugar levels rise because the body is unable to produce the hormone insulin or cannot use the insulin it produces effectively. Diabetes mellitus is currently a global health treath. Alloxan is one of the common diabetogenic agents that is often used to assess the antidiabetic potential of purified compounds and plant extracts in studies involving diabetes. Intermittent fasting is time-restricted feeding, where food can only be eaten at certain times of the day, usually in conjunction with a 16 - 20 hour fast. Several studies have proven that intermittent fasting is effective in reducing weight and stabilizing blood glucose levels. Circadian rhythms are also called biological clocks which refer to behavioral, physiological and molecular changes with a cycle length of about 24 hours. Intermittent fasting can maintain circadian rhythm and regulate the metabolic system. Intermittent fasting results in reductions in energy intake, body weight, body fat, blood pressure, blood glucose, glucose tolerance, and inflammatory markers. This research was conducted to find out whether there is a difference in blood glucose levels when doing intermittent fasting for 12 hours during the day and at night. This research is true experimental research with a Pre-Test and Post-Test Control Group Design research design. Measurement of blood sugar levels in mice (Mus musculus) was carried out before and after treatment. Take samples of mice that weigh 20-40 grams and are 2-3 months old. All of these mice were male and had fasting blood glucose levels >108 mg/dL after alloxan induction. This research has two variables, namely independent and dependent. The independent variable here is the ...