Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Scaffold-guided bone regeneration in large volume tibial segmental defects

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • بيانات النشر:
      Elsevier Inc.
    • الموضوع:
      2021
    • Collection:
      Queensland University of Technology: QUT ePrints
    • نبذة مختصرة :
      Large volume losses in weight bearing long bones are a major challenge in clinical practice. Despite multiple innovations over the last decades, significant limitations subsist in current clinical treatment options which is driving a strong clinical demand for clinically translatable treatment alternatives, including bone tissue engineering applications. Despite these shortcomings, preclinical large animal models of large volume segmental bone defects to investigate the regenerative capacity of bone tissue engineering strategies under clinically relevant conditions are rarely described in literature. We herein present a newly established preclinical ovine animal model for the treatment of XL volume (19 cm 3 ) segmental tibial defects. In eight aged male Merino sheep (age > 6 years) a mid-diaphyseal tibial segmental defect was created and stabilized with a 5.6 mm Dynamic Compression Plate (DCP). We present short-term (3 months) and long-term (12–15 months) results of a pilot study using medical grade Polycaprolactone-Tricalciumphosphate (mPCL-TCP) scaffolds combined with a dose of 2 mg rhBMP-7 delivered in Platelet-Rich- Plasma (PRP). Furthermore, detailed analyses of the mechanical properties of the scaffolds as well as interfragmentary movement (IFM) and DCP-surface strain in vitro and a comprehensive description of the surgical and post-surgery protocol and post-mortem analysis is given.
    • File Description:
      application/pdf
    • Relation:
      https://eprints.qut.edu.au/226458/1/Scaffold_Guided_Bone_Regeneration_XL_bone_volume.pdf; Henkel, Jan, Medeiros Savi, Flavia, Berner, Arne, Fountain, Stephanie, Saifzadeh, Siamak, Steck, Roland, Epari, Devakar R., Woodruff, Maria A., Knackstedt, Mark, Schuetz, Michael A., & Hutmacher, Dietmar W. (2021) Scaffold-guided bone regeneration in large volume tibial segmental defects. Bone, 153, Article number: 116163.; http://purl.org/au-research/grants/arc/IC160100026; https://eprints.qut.edu.au/226458/; Centre for Behavioural Economics, Society & Technology; Centre for Biomedical Technologies; Centre for Transformative Biomimetics in Bioeng; Centre for Healthcare Transformation; Academic Division; Faculty of Business & Law; Faculty of Engineering; School of Mechanical, Medical & Process Engineering; Faculty of Health
    • الدخول الالكتروني :
      https://eprints.qut.edu.au/226458/
    • Rights:
      free_to_read ; http://creativecommons.org/licenses/by-nc-nd/2.5/ ; Crown Copyright 2021. ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
    • الرقم المعرف:
      edsbas.7354BBDD