Multiplex analysis of cytokines/chemokines in K18-hACE mice challenged with SARS-CoV-2 measured at 3- and 7-days post inoculation.

A . Individual animals are plotted, violin plots depict median and quantiles. Low dose = blue, high dose = red. B . Correlation between cytokine levels and viral RNA in the lungs. Significant correlations (p = 0.05) are shown and strength of correlation is depicted according to the colour bar, crossed bars are not significant. Abbreviations: DPI = days post inoculation, G-CSF = granulocyte colony-stimulating factor, GM-CSF = granulocyte-macrophage colony-stimulating factor, INF = interferon, IL = interleukin, KC = keratinocyte chemoattractant, MCP = monocyte chemoattractant protein, MIP = macrophage inflammatory protein, IP = interferon-γ-inducible protein, TNF = tumour necrosis factor. (TIF)