Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Disentangling the link between maternal influences on birth weight and disease risk in 36,211 genotyped mother–child pairs

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Genomics of Sex Differences; Institute for Molecular Medicine Finland; Helsinki Institute of Life Science HiLIFE; Centre of Excellence in Complex Disease Genetics; Helsinki Institute for Information Technology; Statistical and population genetics; Department of Mathematics and Statistics; Department of Public Health; Molecular and Integrative Biosciences Research Programme
    • بيانات النشر:
      Springer
    • الموضوع:
      2024
    • Collection:
      Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto
    • نبذة مختصرة :
      Epidemiological studies have robustly linked lower birth weight to later-life disease risks. These observations may reflect the adverse impact of intrauterine growth restriction on a child's health. However, causal evidence supporting such a mechanism in humans is largely lacking. Using Mendelian Randomization and 36,211 genotyped mother-child pairs from the FinnGen study, we assessed the relationship between intrauterine growth and five common health outcomes (coronary heart disease (CHD), hypertension, statin use, type 2 diabetes and cancer). We proxied intrauterine growth with polygenic scores for maternal effects on birth weight and took into account the transmission of genetic variants between a mother and a child in the analyses. We find limited evidence for contribution of normal variation in maternally influenced intrauterine growth on later-life disease. Instead, we find support for genetic pleiotropy in the fetal genome linking birth weight to CHD and hypertension. Our study illustrates the opportunities that data from genotyped parent-child pairs from a population-based biobank provides for addressing causality of maternal influences.A Mendelian Randomization study with 36,211 mother-child pairs indicates that maternal genetic variants, influencing a child's birth weight, impact the child's risk for common diseases through inheritance and not by effects on intrauterine growth. ; Peer reviewed
    • File Description:
      application/pdf
    • Relation:
      We thank all FinnGen participants, principal investigators, laboratory personnel and data management teams. The FinnGen project is funded by two grants from Business Finland (HUS 4685/31/2016 and UH 4386/31/2016) and the following industry partners: AbbVie Inc., AstraZeneca UK Ltd, Biogen MA Inc., Bristol Myers Squibb (and Celgene Corporation & Celgene International II Sarl), Genentech Inc., Merck Sharp & Dohme LCC, Pfizer Inc., GlaxoSmithKline Intellectual Property Development Ltd., Sanofi US Services Inc., Maze Therapeutics Inc., Janssen Biotech Inc, Novartis AG, and Boehringer Ingelheim International GmbH. Following biobanks are acknowledged for delivering biobank samples to FinnGen: Auria Biobank (www.auria.fi/biopankki), THL Biobank (www.thl.fi/biobank), Helsinki Biobank (www.helsinginbiopankki.fi), Biobank Borealis of Northern Finland (https://www.ppshp.fi/Tutkimus-ja-opetus/Biopankki/Pages/Biobank-Borealis-briefly-in-English.aspx), Finnish Clinical Biobank Tampere (www.tays.fi/en-US/Research_and_development/Finnish_Clinical_Biobank_Tampere), Biobank of Eastern Finland (www.ita-suomenbiopankki.fi/en), Central Finland Biobank (www.ksshp.fi/fi-FI/Potilaalle/Biopankki), Finnish Red Cross Blood Service Biobank (www.veripalvelu.fi/verenluovutus/biopankkitoiminta), Terveystalo Biobank (www.terveystalo.com/fi/Yritystietoa/Terveystalo-Biopankki/Biopankki/) and Arctic Biobank (https://www.oulu.fi/en/university/faculties-and-units/faculty-medicine/northern-finland-birth-cohorts-and-arctic-biobank). All Finnish Biobanks are members of BBMRI.fi infrastructure (www.bbmri.fi). Finnish Biobank Cooperative -FINBB (https://finbb.fi/) is the coordinator of BBMRI-ERIC operations in Finland. The Finnish biobank data can be accessed through the Fingenious (R) services (https://site.fingenious.fi/en/) managed by FINBB. T.T. was funded by Sigrid Juselius Foundation (https://sigridjuselius.fi/en/), the HiLIFE Fellows Program, and the Research Council of Finland (grant number 315589). M.P. was supported by the Research Council of Finland (https://www.aka.fi/en/) grant 338507, Research Council of Finland Center of Excellence in Complex Disease Genetics grant 352795, and the Sigrid Juselius Foundation. Open access funded by Helsinki University Library.; Leinonen , J T , Pirinen , M & Tukiainen , T 2024 , ' Disentangling the link between maternal influences on birth weight and disease risk in 36,211 genotyped mother–child pairs ' , Communications Biology , vol. 7 , no. 1 , 175 . https://doi.org/10.1038/s42003-024-05872-9; ORCID: /0000-0002-1664-1350/work/154560939; ORCID: /0000-0001-7530-6918/work/160779523; http://hdl.handle.net/10138/572183; a4aab6ca-58e6-432c-b9a1-cd44fe899ae9; 85185101462; 001161487300004
    • الدخول الالكتروني :
      http://hdl.handle.net/10138/572183
    • Rights:
      cc_by ; info:eu-repo/semantics/openAccess ; openAccess
    • الرقم المعرف:
      edsbas.721E9900