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Comparison of Monoclonal Gammopathies Linked to Poliovirus or Coxsackievirus vs. Other Infectious Pathogens

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Molecular Mechanisms of Chronic Inflammation in Hematological Diseases (CRCINA-ÉQUIPE 16); Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA); Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE); Université de Nantes (UN)-Université de Nantes (UN)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE); Université de Nantes (UN)-Université de Nantes (UN); Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE); Laboratoire de Biochimie Nantes; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Service de Médecine interne et immunologie clinique Rennes = internal medicine and clinical immunology Rennes; Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Laboratoire de Biochimie CHRU Tours; Morphogénèse et antigénicité du VIH, des Virus des Hépatites et Emergents (MAVIVHe); Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service d'Hématologie Nantes; CHU Amiens-Picardie
    • بيانات النشر:
      CCSD
      MDPI
    • الموضوع:
      2021
    • Collection:
      Université François-Rabelais de Tours: HAL
    • نبذة مختصرة :
      International audience ; Chronic stimulation by infectious pathogens or self-antigen glucosylsphingosine (GlcSph) can lead to monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Novel assays such as the multiplex infectious antigen microarray (MIAA) and GlcSph assays, permit identification of targets for >60% purified monoclonal immunoglobulins (Igs). Searching for additional targets, we selected 28 purified monoclonal Igs whose antigen was not represented on the MIAA and GlcSph assays; their specificity of recognition was then analyzed using microarrays consisting of 3760 B-cell epitopes from 196 pathogens. The peptide sequences PALTAVETG and PALTAAETG of the VP1 coat proteins of human poliovirus 1/3 and coxsackievirus B1/B3, respectively, were specifically recognized by 6/28 monoclonal Igs. Re-analysis of patient cohorts showed that purified monoclonal Igs from 10/155 MGUS/SM (6.5%) and 3/147 MM (2.0%) bound to the PALTAVETG or PALTAAETG epitopes. Altogether, PALTAV/AETG-initiated MGUS are not rare and few seem to evolve toward myeloma.
    • الرقم المعرف:
      10.3390/cells10020438
    • الدخول الالكتروني :
      https://inserm.hal.science/inserm-03148367
      https://inserm.hal.science/inserm-03148367v1/document
      https://inserm.hal.science/inserm-03148367v1/file/cells-10-00438.pdf
      https://doi.org/10.3390/cells10020438
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.714AD66E