Contributors: Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou; Institut de recherche en santé, environnement et travail (Irset); Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ); EHESP-Irset (EHESP-Irset); École des Hautes Études en Santé Publique EHESP (EHESP); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Université de Lorraine (UL); Centre de recherche Cardio-Thoracique de Bordeaux Bordeaux (CRCTB); Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux-Institut National de la Santé et de la Recherche Médicale (INSERM); CHU Bordeaux; IMRB - GEIC2O/"Genetic and Environmental Interactions in COPD, Cystic fibrosis and Other (rare) respiratory diseases" Créteil (U955 Inserm - UPEC); Institut Mondor de Recherche Biomédicale (IMRB); Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); Institut Santé-Travail Paris-Est Créteil; Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine); Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); Centre Hospitalier Intercommunal de Créteil (CHIC); Bordeaux population health (BPH); Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM); CHI Créteil; Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE); Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-CHU Caen; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse Caen (UNICANCER/CRLC); Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM); CHU Caen; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN); Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Université Grenoble Alpes (UGA); Hôpital Michallon; CHU Rouen; Normandie Université (NU); Institut national de recherche et de sécurité (Paris) (INRS (Paris)); This work was supported by the French National Health Insurance (Occupational Risk Prevention Department), French Ministry of Labor and Social Relations, French Agency for Food, Environmental and Occupational Health and Safety (ANSES grant 07-CRD-51, EST 2006/1/43, EST 2009/68).
نبذة مختصرة : International audience ; BACKGROUND: Previous studies have inconsistently reported associations between Refractory Ceramic Fibers (RCF) or Mineral Wool Fibers (MWF) and the presence of pleural plaques (PP). Moreover, all these studies were based on Chest X-Ray, known to be associated with a poor sensitivity for the diagnosis of PP. RESEARCH QUESTION: Does the risk of pleural plaques increase with cumulative exposure to RCF, MWF and silica ? and if yes, do these dose-response relationships depend on the co-exposure to asbestos or conversely, are the dose-response relationships for asbestos modified by co-exposure to RCF, MWF and silica ? STUDY DESIGN AND METHODS: Volunteer workers were invited to participate in a CT-scan screening program for asbestos-related diseases in France. Asbestos exposure was assessed by industrial hygienists and exposure to RCF, MWF and silica was determined by using Job-Exposure Matrices. A Cumulative Exposure Index (CEI) was then calculated for each subject and separately for each of the 4 mineral particle exposures. All available CT-scans were submitted to randomized, double reading by a panel of radiologists. RESULTS: In this cohort of 5,457 subjects, we found a significant dose-response relationships, after adjustment for asbestos exposure between CEI to RCF or MWF and the risk of PP (OR= 1.29 [1.00-1.67] and OR= 1.84 [1.49-2.27] for the highest CEI quartile respectively). Moreover, significant interactions were found between asbestos on one side and respectively MWF or RCF on the other side. INTERPRETATION: This study suggests the existence of a significant association between exposure to RCF and MWF and the presence of PP in a large population previously exposed to asbestos and screened by CT-scan.
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