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A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles

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  • معلومة اضافية
    • بيانات النشر:
      Royal Society of Chemistry
    • الموضوع:
      2021
    • Collection:
      University of Hull: Repository@Hull
    • نبذة مختصرة :
      The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels-Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans¬-cyclooctene (TCO) functionalised phospholipid (40-50% RCY), which was incorporated into MBs (40-50% RCY). To demonstrate the potential of producing 18F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.
    • ISSN:
      1359-7345
    • Relation:
      https://hull-repository.worktribe.com/output/3856853; Chemical Communications; https://hull-repository.worktribe.com/file/3856853/1/Accepted%20article
    • الرقم المعرف:
      10.1039/d1cc04790f
    • Rights:
      openAccess ; http://creativecommons.org/licenses/by/3.0
    • الرقم المعرف:
      edsbas.6DA178DD