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Oxysterols induce apoptosis and accumulation of cell cycle at G2/M phase in the human monocytic THP-1 cell line

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Hee-Kyoung Lim; Hee-Kyoung Kang; Jin-Won Hyun; Myung-Hee Chung; Yun-Sil Lee; Jae-Hwa Lee; Moonjae Cho; Youn-Woo Kim; Bum-Joon Kim; Eun-Sook Yoo; Lee, Yun Sil
    • الموضوع:
      2003
    • نبذة مختصرة :
      The cytotoxic activity of oxysterols, 7棺-hydroxycholesterol (7棺-OHC) and 25-hydroxycholesterol (25-OHC), has been evaluated using various leukemia cell lines. Among the tested cell lines, both oxysterols showed the highest cytotoxicity to THP-1, human monocytic leukemia cell line. These oxysterols induced apoptosis through down-regulation of Bcl-2 expression and activation of caspases. Also, the oxysterols showed the accumulation at G2/M phase of cell cycle through down-regulation of cyclin B1 expression. Taken together, these results indicated that both 7棺-OHC and 25-OHC inhibited the proliferation of THP-1 cells through apoptosis and cell cycle accumulation at G2/M phase. ; open
    • File Description:
      1389~1399
    • ISSN:
      0024-3205
      1879-0631
    • Relation:
      LIFE SCIENCES; J02167; OAK-2003-00677; https://ir.ymlib.yonsei.ac.kr/handle/22282913/113837; http://www.sciencedirect.com/science/article/pii/S0024320502023779; T200304418; LIFE SCIENCES, Vol.72(12) : 1389-1399, 2003
    • الرقم المعرف:
      10.1016/S0024-3205(02)02377-9
    • Rights:
      CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; not free
    • الرقم المعرف:
      edsbas.6C1A3CAE