Subgroup analyses of hazard ratios for the development of advanced liver fibrosis (APRI value of ≥0.5) in participants belonging to the highest baseline HOMA-IR quartile (Q4) compared with those belonging to the lowest baseline HOMA-IR quartile (Q1).

*Adjusted for age, sex, year of examination, SBP, antihypertensive medications, regular exercise, current alcohol consumption, smoking status, BMI, waist circumference, HbA1c, hs-CRP, LDL cholesterol, HDL cholesterol, triglyceride, and use of antidyslipidemic drugs. † Current alcohol consumption defined as daily alcohol consumption above the median value (12 g/day for men, 2 g/day for women). ‡ Dyslipidemia was defined as total cholesterol ≥200 mg/dL, triglyceride levels ≥150 mg/dL, LDL cholesterol levels ≥130 mg/dL, HDL cholesterol levels <40 mg/dL in men and <50 mg/dL in women, or use of antidyslipidemic drugs. Abbreviations: HOMA-IR, homeostasis model assessment of insulin resistance; SBP, systolic blood pressure; BMI, body mass index; HbA1c, hemoglobin A1c; hs-CRP, high-sensitivity C-reactive protein; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HR, hazard ratio; CI, confidence interval.