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RILEY SYMPOSIUM Cell-Cycle-Based Strategies to Drive Myocardial Repair

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  • معلومة اضافية
    • Contributors:
      The Pennsylvania State University CiteSeerX Archives
    • Collection:
      CiteSeerX
    • نبذة مختصرة :
      Ó The Author(s) 2009. This article is published with open access at Springerlink.com Abstract Cardiomyocytes exhibit robust proliferative activity during development. After birth, cardiomyocyte proliferation is markedly reduced. Consequently, regenerative growth in the postnatal heart via cardiomyocyte proliferation (and, by inference, proliferation of stem-cellderived cardiomyocytes) is limited and often insufficient to affect repair following injury. Here, we review studies wherein cardiomyocyte cell cycle proliferation was induced via targeted expression of cyclin D2 in postnatal hearts. Cyclin D2 expression resulted in a greater than 500fold increase in cell cycle activity in transgenic mice as compared to their nontransgenic siblings. Induced cell cycle activity resulted in infarct regression and concomitant improvement in cardiac hemodynamics following coronary artery occlusion. These studies support the notion that cell-cycle-based strategies can be exploited to drive myocardial repair following injury.
    • File Description:
      application/zip
    • Relation:
      http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.359.669
    • الدخول الالكتروني :
      http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.359.669
    • Rights:
      Metadata may be used without restrictions as long as the oai identifier remains attached to it.
    • الرقم المعرف:
      edsbas.6A75070